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Assay Detail

CHEMBL1936716

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human HepG2/C3A cells after 24 hrs by neutral red uptake assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type HepG2/C3A
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Straightforward palladium-mediated synthesis and biological evaluation of benzo[j]phenanthridine-7,12-diones as anti-tuberculosis agents.
Cappoen D, Jacobs J, Nguyen Van T, Claessens S, Diels G, Anthonissen R, Einarsdottir T, Fauville M, Verschaeve L, Huygen K, De Kimpe N.
Eur J Med Chem (2012) 48 : 57 -68
PubMed 22182928 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 6.18 9.65

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL23393 SODIUM LAURYL SULFATE 3.0 1 9.65
CHEMBL1935198 1 6.02
CHEMBL1935193 1 5.96
CHEMBL1935196 1 5.83
CHEMBL1935191 1 5.82
CHEMBL1935192 1 5.81
CHEMBL1935197 1 5.62
CHEMBL1935195 1 5.49
CHEMBL1935194 1 5.40
CHEMBL64 ISONIAZID 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL23393 SODIUM LAURYL SULFATE IC50 = 0.222 nM 9.65
CHEMBL1935198 IC50 = 950.0 nM 6.02
CHEMBL1935193 IC50 = 1090.0 nM 5.96
CHEMBL1935196 IC50 = 1480.0 nM 5.83
CHEMBL1935191 IC50 = 1510.0 nM 5.82
CHEMBL1935192 IC50 = 1560.0 nM 5.81
CHEMBL1935197 IC50 = 2400.0 nM 5.62
CHEMBL1935195 IC50 = 3210.0 nM 5.49
CHEMBL1935194 IC50 = 3960.0 nM 5.40
CHEMBL64 ISONIAZID IC50 - -