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Assay Detail

CHEMBL1942971

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]QNB from human M1 receptor by liquid scintillation counting
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Muscarinic acetylcholine receptor M1 (CHEMBL216)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Multi-receptor drug design: Haloperidol as a scaffold for the design and synthesis of atypical antipsychotic agents.
Peprah K, Zhu XY, Eyunni SV, Setola V, Roth BL, Ablordeppey SY.
Bioorg Med Chem (2012) 20 : 1291 -1297
PubMed 22245230 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 7.27 8.74

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL42 CLOZAPINE 4.0 1 8.74
CHEMBL54 HALOPERIDOL 4.0 1 5.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL42 CLOZAPINE Ki = 1.8 nM 8.74
CHEMBL54 HALOPERIDOL Ki = 1600.0 nM 5.80