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Assay Detail

CHEMBL1944113

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]8-OH-DPAT from human 5HT1A receptor by liquid scintillation counting
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 1A (CHEMBL214)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Multi-receptor drug design: Haloperidol as a scaffold for the design and synthesis of atypical antipsychotic agents.
Peprah K, Zhu XY, Eyunni SV, Setola V, Roth BL, Ablordeppey SY.
Bioorg Med Chem (2012) 20 : 1291 -1297
PubMed 22245230 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 7.19 8.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1940418 1 8.96
CHEMBL1940420 1 8.44
CHEMBL1940419 1 8.21
CHEMBL1940415 1 8.07
CHEMBL1940417 1 7.64
CHEMBL1940412 1 7.62
CHEMBL1940414 1 7.60
CHEMBL140872 1 7.52
CHEMBL1940404 1 7.13
CHEMBL1940411 1 7.10
CHEMBL1940416 1 7.03
CHEMBL1940408 1 6.95
CHEMBL1940413 1 6.81
CHEMBL1940409 1 6.78
CHEMBL1940406 1 6.77
CHEMBL1940403 1 6.50
CHEMBL1940405 1 6.34
CHEMBL1940407 1 6.21
CHEMBL1940402 1 6.18
CHEMBL1940410 1 5.97

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1940418 Ki = 1.1 nM 8.96
CHEMBL1940420 Ki = 3.6 nM 8.44
CHEMBL1940419 Ki = 6.2 nM 8.21
CHEMBL1940415 Ki = 8.6 nM 8.07
CHEMBL1940417 Ki = 23.0 nM 7.64
CHEMBL1940412 Ki = 24.0 nM 7.62
CHEMBL1940414 Ki = 25.0 nM 7.60
CHEMBL140872 Ki = 30.5 nM 7.52
CHEMBL1940404 Ki = 74.0 nM 7.13
CHEMBL1940411 Ki = 80.0 nM 7.10
CHEMBL1940416 Ki = 93.1 nM 7.03
CHEMBL1940408 Ki = 112.0 nM 6.95
CHEMBL1940413 Ki = 154.0 nM 6.81
CHEMBL1940409 Ki = 166.0 nM 6.78
CHEMBL1940406 Ki = 169.0 nM 6.77
CHEMBL1940403 Ki = 317.0 nM 6.50
CHEMBL1940405 Ki = 454.0 nM 6.34
CHEMBL1940407 Ki = 613.0 nM 6.21
CHEMBL1940402 Ki = 658.0 nM 6.18
CHEMBL1940410 Ki = 1080.0 nM 5.97