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Compound Detail

CHEMBL1940407

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[O-][S+](CCCN1CCC(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1

Basic Information

ChEMBL ID CHEMBL1940407
Phase Preclinical
Structure Type MOL
InChI Key YUXGGLCIOFCGBA-UHFFFAOYSA-N
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

379.9
MW (Da)
4.86
ALogP
2
HBA
0
HBD
26.3
PSA (Ų)
0.67
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H23ClFNOS
MW 379.93
Aromatic Rings 2
Heavy Atoms 25
NP-Likeness -1.01

Activity Summary

Ki 5 meas. best 7.46

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(4) dopamine receptor
CHEMBL3361
Ki 7.46 7.46 35.0 1
5-hydroxytryptamine receptor 2A
CHEMBL224
Ki 6.65 6.65 222.0 1
D(3) dopamine receptor
CHEMBL234
Ki 6.61 6.61 243.0 1
5-hydroxytryptamine receptor 1A
CHEMBL214
Ki 6.21 6.21 613.0 1
D(2) dopamine receptor
CHEMBL217
Ki 6.0 6.0 998.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
22245230 10.1016/j.bmc.2011.12.019 D(2) dopamine receptor 1
22245230 10.1016/j.bmc.2011.12.019 D(3) dopamine receptor 1
22245230 10.1016/j.bmc.2011.12.019 D(4) dopamine receptor 1
22245230 10.1016/j.bmc.2011.12.019 5-hydroxytryptamine receptor 1A 1
22245230 10.1016/j.bmc.2011.12.019 5-hydroxytryptamine receptor 2A 1
22245230 10.1016/j.bmc.2011.12.019 5-hydroxytryptamine receptor 2C 1

Data from ChEMBL 36 via Core Engine