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Assay Detail

CHEMBL1947367

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human A2780 cells assessed as cell viability after 72 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A2780
Confidence 1 — Organism
Curated By Autocuration

Target

A2780 (CHEMBL614004)
Type CELL-LINE
Organism Homo sapiens

Publication

Asymmetric synthesis and cytotoxicity of (-)-saframycin A analogues.
Dong W, Liu W, Yan Z, Liao X, Guan B, Wang N, Liu Z.
Eur J Med Chem (2012) 49 : 239 -244
PubMed 22284268 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 7.77 8.56

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL452709 SAFRAMYCIN A 1 8.56
CHEMBL1946532 1 8.44
CHEMBL1946681 1 8.41
CHEMBL1946534 1 8.29
CHEMBL1946680 1 8.14
CHEMBL1946679 1 7.95
CHEMBL1946682 1 7.92
CHEMBL1946362 1 7.84
CHEMBL1946361 1 7.76
CHEMBL1946531 1 7.64
CHEMBL1946363 1 7.59
CHEMBL1946683 1 7.56
CHEMBL1946678 1 7.53
CHEMBL1946528 1 7.47
CHEMBL1946360 1 7.40
CHEMBL1946530 1 7.36
CHEMBL1946685 1 7.35
CHEMBL1946533 1 7.33
CHEMBL1946684 1 7.01

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL452709 SAFRAMYCIN A IC50 = 2.75 nM 8.56
CHEMBL1946532 IC50 = 3.67 nM 8.44
CHEMBL1946681 IC50 = 3.87 nM 8.41
CHEMBL1946534 IC50 = 5.11 nM 8.29
CHEMBL1946680 IC50 = 7.17 nM 8.14
CHEMBL1946679 IC50 = 11.15 nM 7.95
CHEMBL1946682 IC50 = 11.95 nM 7.92
CHEMBL1946362 IC50 = 14.42 nM 7.84
CHEMBL1946361 IC50 = 17.46 nM 7.76
CHEMBL1946531 IC50 = 22.69 nM 7.64
CHEMBL1946363 IC50 = 25.46 nM 7.59
CHEMBL1946683 IC50 = 27.36 nM 7.56
CHEMBL1946678 IC50 = 29.63 nM 7.53
CHEMBL1946528 IC50 = 33.74 nM 7.47
CHEMBL1946360 IC50 = 39.79 nM 7.40
CHEMBL1946530 IC50 = 43.93 nM 7.36
CHEMBL1946685 IC50 = 45.03 nM 7.35
CHEMBL1946533 IC50 = 47.14 nM 7.33
CHEMBL1946684 IC50 = 98.05 nM 7.01