Assay Detail
Binding
CHEMBL1947445
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior substrate addition measured for 10 mins by spectrophotometry
16
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of non-basic inhibitors of urokinase-type plasminogen activator (uPA).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.25 | 4.25 |
| Ki | 4 | 6.19 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL158405 | — | — | 1 | 7.00 |
| CHEMBL107955 | — | — | 1 | 6.31 |
| CHEMBL104937 | — | — | 2 | 5.25 |
| CHEMBL324168 | — | — | 2 | - |
| CHEMBL1945236 | — | — | 1 | - |
| CHEMBL1945669 | — | — | 1 | - |
| CHEMBL1945756 | — | — | 1 | - |
| CHEMBL1945757 | — | — | 1 | - |
| CHEMBL1945764 | — | — | 1 | - |
| CHEMBL1945765 | — | — | 1 | - |
| CHEMBL1945766 | — | — | 1 | - |
| CHEMBL1945767 | — | — | 1 | - |
| CHEMBL1945918 | — | — | 1 | - |
| CHEMBL112995 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL158405 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL107955 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL104937 | — | Ki | = | 5640.0 | nM | 5.25 |
| CHEMBL104937 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL324168 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1945236 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1945669 | — | IC50 | > | 125000.0 | nM | - |
| CHEMBL1945756 | — | IC50 | > | 62000.0 | nM | - |
| CHEMBL1945757 | — | IC50 | > | 62000.0 | nM | - |
| CHEMBL1945764 | — | IC50 | > | 62000.0 | nM | - |
| CHEMBL1945765 | — | IC50 | > | 62000.0 | nM | - |
| CHEMBL1945766 | — | IC50 | > | 62000.0 | nM | - |
| CHEMBL1945767 | — | IC50 | > | 62000.0 | nM | - |
| CHEMBL1945918 | — | IC50 | > | 62000.0 | nM | - |
| CHEMBL112995 | — | IC50 | > | 62000.0 | nM | - |
| CHEMBL324168 | — | IC50 | > | 62000.0 | nM | - |