Assay Detail
Binding
CHEMBL1949348
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Displacement of [3H]-5HT from human SERT
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.65 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41140 | 6-NITROQUIPAZINE | — | 1 | 9.77 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41140 | 6-NITROQUIPAZINE | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL18772 | QUIPAZINE | Ki | = | 30.0 | nM | 7.52 |