Assay Detail
Functional
CHEMBL1949358
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Thoracic aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Design, synthesis and biological evaluation of 6-substituted aminocarbonyl benzimidazole derivatives as nonpeptidic angiotensin II AT1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.22 | 8.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1945010 | — | — | 1 | 8.50 |
| CHEMBL1947131 | — | — | 1 | 8.32 |
| CHEMBL1947129 | — | — | 1 | 8.16 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1945010 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL1947131 | — | Kd | = | 4.786 | nM | 8.32 |
| CHEMBL1947129 | — | Kd | = | 6.918 | nM | 8.16 |
| CHEMBL191 | LOSARTAN | Kd | = | 12.59 | nM | 7.90 |