Assay Detail
Functional
CHEMBL1954681
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Agonist activity at human ERbeta expressed in HEC-1 cells coexpressing beta-gal assessed as luciferase activity after 24 hrs by reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEC-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Diarylpropionitrile (DPN) enantiomers: synthesis and evaluation of estrogen receptor β-selective ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.80 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 9.70 |
| CHEMBL1950809 | — | — | 1 | 8.52 |
| CHEMBL198159 | — | — | 1 | 8.49 |
| CHEMBL334773 | DIARYLPROPIONITRILE | — | 1 | 8.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1950809 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL198159 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL334773 | DIARYLPROPIONITRILE | EC50 | = | 3.3 | nM | 8.48 |