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Compound Detail

CHEMBL1950809

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N#C[C@@H](Cc1ccc(O)cc1)c1ccc(O)cc1

Basic Information

ChEMBL ID CHEMBL1950809
Phase Preclinical
Structure Type MOL
InChI Key GHZHWDWADLAOIQ-CYBMUJFWSA-N
3
Targets
9
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

239.3
MW (Da)
2.95
ALogP
3
HBA
2
HBD
64.2
PSA (Ų)
0.87
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C15H13NO2
MW 239.27
Aromatic Rings 2
Heavy Atoms 18
NP-Likeness 0.27

Activity Summary

EC50 8 meas. best 9.12
Ki 1 meas. best 8.74

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Estrogen receptor beta
CHEMBL242
EC50 9.12 8.3875 0.8 4
Estrogen receptor beta
CHEMBL3021
Ki 8.74 8.74 1.8 1
Estrogen receptor
CHEMBL206
EC50 8.21 6.8075 6.2 4

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
22122563 10.1021/jm201436k Estrogen receptor beta 12
22122563 10.1021/jm201436k Estrogen receptor 11
22122563 10.1021/jm201436k Unchecked 5

Data from ChEMBL 36 via Core Engine