Assay Detail
Binding
CHEMBL1954845
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Inhibition of human endothelial lipase overexpressed in HUVEC cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate addition by micelle assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of boronic acid inhibitors of endothelial lipase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.66 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL485946 | — | — | 1 | 7.00 |
| CHEMBL1952298 | — | — | 1 | 6.70 |
| CHEMBL1952297 | — | — | 1 | 6.50 |
| CHEMBL1952296 | — | — | 1 | 6.33 |
| CHEMBL1952307 | — | — | 1 | 6.00 |
| CHEMBL1949700 | — | — | 1 | 6.00 |
| CHEMBL1952308 | — | — | 1 | 5.96 |
| CHEMBL1952303 | — | — | 1 | 5.96 |
| CHEMBL1952304 | — | — | 1 | 5.96 |
| CHEMBL1952309 | — | — | 1 | 5.89 |
| CHEMBL1952305 | — | — | 1 | 5.85 |
| CHEMBL1952310 | — | — | 1 | 5.80 |
| CHEMBL1952313 | — | — | 1 | 5.77 |
| CHEMBL1952311 | — | — | 1 | 5.54 |
| CHEMBL1952312 | — | — | 1 | 5.51 |
| CHEMBL1952295 | — | — | 1 | 5.40 |
| CHEMBL1952300 | — | — | 1 | 5.30 |
| CHEMBL1952302 | — | — | 1 | 5.22 |
| CHEMBL1952301 | — | — | 1 | 4.96 |
| CHEMBL1952294 | — | — | 1 | 4.72 |
| CHEMBL1952299 | — | — | 1 | 4.66 |
| CHEMBL140780 | TOLYL BORONIC ACID | — | 1 | 4.66 |
| CHEMBL1952306 | — | — | 1 | 4.46 |
| CHEMBL1952314 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL485946 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1952298 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1952297 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1952296 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL1952307 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1949700 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1952308 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1952303 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1952304 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1952309 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1952305 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1952310 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1952313 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1952311 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1952312 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1952295 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1952300 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1952302 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1952301 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1952294 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL1952299 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL140780 | TOLYL BORONIC ACID | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL1952306 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL1952314 | — | IC50 | = | 300000.0 | nM | - |