Compound Detail
CHEMBL1952298
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Basic Information
| ChEMBL ID | CHEMBL1952298 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CGMZNRHLKZJXFR-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
276.2
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 6.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Endothelial lipase CHEMBL5080 | IC50 | 6.7 | 6.2 | 200.0 | 2 |
| Lipoprotein lipase CHEMBL2060 | IC50 | 5.82 | 5.06 | 1500.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Endothelial lipase | IC50 | = | 200.0 | nM | 6.7 | Inhibition of human endothelial lipase overexpressed in HUVEC cells using bis-BD... | 22225633 |
| Lipoprotein lipase | IC50 | = | 1500.0 | nM | 5.82 | Inhibition of human lipoprotein lipase expressed in HEK293 cells using bis-BD-PC... | 22225633 |
| Endothelial lipase | IC50 | = | 2000.0 | nM | 5.7 | Inhibition of human endothelial lipase expressed using recombinant adenovirus us... | 22225633 |
| Lipoprotein lipase | IC50 | = | 50000.0 | nM | 4.3 | Inhibition of human lipoprotein lipase expressed using recombinant adenovirus us... | 22225633 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22225633 | 10.1016/j.bmcl.2011.12.043 | Endothelial lipase | 2 |
| 22225633 | 10.1016/j.bmcl.2011.12.043 | Lipoprotein lipase | 2 |
| 22225633 | 10.1016/j.bmcl.2011.12.043 | Unchecked | 2 |
Data from ChEMBL 36 via Core Engine