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Assay Detail

CHEMBL1955702

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma brucei MITat 427 clone 221a trypomastigotes after 3 days by alamar blue assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei (CHEMBL612849)
Type ORGANISM
Organism Trypanosoma brucei

Publication

Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
Caminos AP, Panozzo-Zenere EA, Wilkinson SR, Tekwani BL, Labadie GR.
Bioorg Med Chem Lett (2012) 22 : 1712 -1715
PubMed 22248858 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 6.19 7.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1950466 1 7.21
CHEMBL280180 1 7.01
CHEMBL1950479 1 6.96
CHEMBL1950467 1 6.85
CHEMBL1950476 1 6.77
CHEMBL1950478 1 6.72
CHEMBL1950477 1 6.72
CHEMBL1950475 1 6.72
CHEMBL1950468 1 6.70
CHEMBL1950463 1 6.66
CHEMBL1950461 1 6.21
CHEMBL1950469 1 6.21
CHEMBL1950474 1 6.02
CHEMBL1950460 1 5.93
CHEMBL290960 NIFURTIMOX 4.0 1 5.77
CHEMBL1950462 1 5.69
CHEMBL197209 1 5.69
CHEMBL23440 1 5.50
CHEMBL1950473 1 5.26
CHEMBL1950464 1 5.26
CHEMBL1950459 1 5.19
CHEMBL277864 1 5.15
CHEMBL1950470 1 -
CHEMBL1950471 1 -
CHEMBL1950472 1 -
CHEMBL1950465 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1950466 IC50 = 62.0 nM 7.21
CHEMBL280180 IC50 = 97.0 nM 7.01
CHEMBL1950479 IC50 = 110.0 nM 6.96
CHEMBL1950467 IC50 = 140.0 nM 6.85
CHEMBL1950476 IC50 = 170.0 nM 6.77
CHEMBL1950478 IC50 = 190.0 nM 6.72
CHEMBL1950477 IC50 = 190.0 nM 6.72
CHEMBL1950475 IC50 = 190.0 nM 6.72
CHEMBL1950468 IC50 = 200.0 nM 6.70
CHEMBL1950463 IC50 = 220.0 nM 6.66
CHEMBL1950461 IC50 = 610.0 nM 6.21
CHEMBL1950469 IC50 = 620.0 nM 6.21
CHEMBL1950474 IC50 = 960.0 nM 6.02
CHEMBL1950460 IC50 = 1180.0 nM 5.93
CHEMBL290960 NIFURTIMOX IC50 = 1700.0 nM 5.77
CHEMBL1950462 IC50 = 2040.0 nM 5.69
CHEMBL197209 IC50 = 2030.0 nM 5.69
CHEMBL23440 IC50 = 3200.0 nM 5.50
CHEMBL1950473 IC50 = 5500.0 nM 5.26
CHEMBL1950464 IC50 = 5500.0 nM 5.26
CHEMBL1950459 IC50 = 6450.0 nM 5.19
CHEMBL277864 IC50 = 7080.0 nM 5.15
CHEMBL1950470 IC50 > 10000.0 nM -
CHEMBL1950471 IC50 > 10000.0 nM -
CHEMBL1950472 IC50 > 10000.0 nM -
CHEMBL1950465 IC50 > 10000.0 nM -