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Assay Detail

CHEMBL1955703

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma cruzi clone CL-Brener epimastigotes after 14 days by alamar blue assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
Caminos AP, Panozzo-Zenere EA, Wilkinson SR, Tekwani BL, Labadie GR.
Bioorg Med Chem Lett (2012) 22 : 1712 -1715
PubMed 22248858 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 5.91 6.14

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1950476 1 6.14
CHEMBL1950477 1 6.13
CHEMBL280180 1 6.12
CHEMBL1950466 1 6.11
CHEMBL1950479 1 6.10
CHEMBL1950478 1 6.09
CHEMBL1950475 1 6.09
CHEMBL1950468 1 6.00
CHEMBL1950467 1 5.74
CHEMBL290960 NIFURTIMOX 4.0 1 5.68
CHEMBL1950465 1 5.64
CHEMBL1950461 1 5.09
CHEMBL1950459 1 -
CHEMBL277864 1 -
CHEMBL197209 1 -
CHEMBL1950460 1 -
CHEMBL1950462 1 -
CHEMBL1950474 1 -
CHEMBL1950473 1 -
CHEMBL1950472 1 -
CHEMBL1950471 1 -
CHEMBL1950470 1 -
CHEMBL1950469 1 -
CHEMBL23440 1 -
CHEMBL1950463 1 -
CHEMBL1950464 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1950476 IC50 = 730.0 nM 6.14
CHEMBL1950477 IC50 = 740.0 nM 6.13
CHEMBL280180 IC50 = 760.0 nM 6.12
CHEMBL1950466 IC50 = 780.0 nM 6.11
CHEMBL1950479 IC50 = 800.0 nM 6.10
CHEMBL1950478 IC50 = 820.0 nM 6.09
CHEMBL1950475 IC50 = 810.0 nM 6.09
CHEMBL1950468 IC50 = 990.0 nM 6.00
CHEMBL1950467 IC50 = 1830.0 nM 5.74
CHEMBL290960 NIFURTIMOX IC50 = 2100.0 nM 5.68
CHEMBL1950465 IC50 = 2300.0 nM 5.64
CHEMBL1950461 IC50 = 8170.0 nM 5.09
CHEMBL1950459 IC50 > 10000.0 nM -
CHEMBL277864 IC50 > 10000.0 nM -
CHEMBL197209 IC50 > 10000.0 nM -
CHEMBL1950460 IC50 > 10000.0 nM -
CHEMBL1950462 IC50 > 10000.0 nM -
CHEMBL1950474 IC50 > 10000.0 nM -
CHEMBL1950473 IC50 > 10000.0 nM -
CHEMBL1950472 IC50 > 10000.0 nM -
CHEMBL1950471 IC50 > 10000.0 nM -
CHEMBL1950470 IC50 > 10000.0 nM -
CHEMBL1950469 IC50 > 10000.0 nM -
CHEMBL23440 IC50 > 10000.0 nM -
CHEMBL1950463 IC50 > 10000.0 nM -
CHEMBL1950464 IC50 > 10000.0 nM -