Assay Detail
Binding
CHEMBL1958677
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Inhibition of ovine COX-1 by enzyme immuno assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-1 and C-3 substituted indole Schiff bases as selective COX-2 inhibitors: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.66 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 6.89 |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 6.46 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.11 |
| CHEMBL1957878 | — | — | 1 | 4.21 |
| CHEMBL1957877 | — | — | 1 | 4.17 |
| CHEMBL1957879 | — | — | 1 | 4.11 |
| CHEMBL1957884 | — | — | 1 | 4.10 |
| CHEMBL1957881 | — | — | 1 | 4.09 |
| CHEMBL1957886 | — | — | 1 | 4.07 |
| CHEMBL1957880 | — | — | 1 | 4.04 |
| CHEMBL1957882 | — | — | 1 | 4.02 |
| CHEMBL1957883 | — | — | 1 | - |
| CHEMBL1957885 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL25 | ASPIRIN | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL118 | CELECOXIB | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1957878 | — | IC50 | = | 62300.0 | nM | 4.21 |
| CHEMBL1957877 | — | IC50 | = | 68400.0 | nM | 4.17 |
| CHEMBL1957879 | — | IC50 | = | 78200.0 | nM | 4.11 |
| CHEMBL1957884 | — | IC50 | = | 80200.0 | nM | 4.10 |
| CHEMBL1957881 | — | IC50 | = | 81500.0 | nM | 4.09 |
| CHEMBL1957886 | — | IC50 | = | 86100.0 | nM | 4.07 |
| CHEMBL1957880 | — | IC50 | = | 91100.0 | nM | 4.04 |
| CHEMBL1957882 | — | IC50 | = | 95500.0 | nM | 4.02 |
| CHEMBL1957883 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1957885 | — | IC50 | > | 100000.0 | nM | - |