Assay Detail
Binding
CHEMBL1959073
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ovine COX1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Nitric oxide release is not required to decrease the ulcerogenic profile of nonsteroidal anti-inflammatory drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.35 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1958348 | — | — | 1 | 7.52 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.00 |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 6.52 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.54 |
| CHEMBL1958349 | — | — | 1 | 5.19 |
| CHEMBL1958350 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1958348 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL25 | ASPIRIN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1958349 | — | IC50 | = | 6440.0 | nM | 5.19 |
| CHEMBL1958350 | — | IC50 | > | 100000.0 | nM | - |