Assay Detail
Binding
CHEMBL1959307
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Displacement of [3H]RX821002 from human Alpha-2C adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancement.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.03 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 7.75 |
| CHEMBL1956906 | — | — | 1 | 5.21 |
| CHEMBL1956905 | — | — | 1 | 5.13 |
| CHEMBL1956899 | — | — | 1 | - |
| CHEMBL1956900 | — | — | 1 | - |
| CHEMBL1956901 | — | — | 1 | - |
| CHEMBL1956902 | — | — | 1 | - |
| CHEMBL1956903 | — | — | 1 | - |
| CHEMBL1956904 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10316 | IDAZOXAN | Ki | = | 17.78 | nM | 7.75 |
| CHEMBL1956906 | — | Ki | = | 6165.95 | nM | 5.21 |
| CHEMBL1956905 | — | Ki | = | 7413.1 | nM | 5.13 |
| CHEMBL1956899 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1956900 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1956901 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1956902 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1956903 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1956904 | — | Ki | > | 10000.0 | nM | - |