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Assay Detail

CHEMBL1960332

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antifungal activity against Trichophyton rubrum IBT 29284 after 7 days by micro broth dilution method
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trichophyton rubrum
Confidence 1 — Organism
Curated By Autocuration

Target

Trichophyton rubrum (CHEMBL612649)
Type ORGANISM
Organism Trichophyton rubrum

Publication

Disparate SAR data of griseofulvin analogues for the dermatophytes Trichophyton mentagrophytes, T. rubrum, and MDA-MB-231 cancer cells.
Rønnest MH, Raab MS, Anderhub S, Boesen S, Krämer A, Larsen TO, Clausen MH.
J Med Chem (2012) 55 : 652 -660
PubMed 22191585 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.82 6.42

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL562 GRISEOFULVIN 4.0 1 6.42
CHEMBL522763 1 6.21
CHEMBL489536 1 6.16
CHEMBL1956511 1 6.08
CHEMBL1956519 1 6.02
CHEMBL491114 1 6.00
CHEMBL521969 1 5.96
CHEMBL490124 1 5.89
CHEMBL491938 1 5.89
CHEMBL1956508 1 5.89
CHEMBL1956512 1 5.82
CHEMBL491757 1 5.82
CHEMBL490548 1 5.80
CHEMBL489517 1 5.70
CHEMBL490921 1 5.60
CHEMBL1956514 1 5.58
CHEMBL489537 1 5.51
CHEMBL523820 1 5.21
CHEMBL522298 1 5.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL562 GRISEOFULVIN IC50 = 380.0 nM 6.42
CHEMBL522763 IC50 = 620.0 nM 6.21
CHEMBL489536 IC50 = 690.0 nM 6.16
CHEMBL1956511 IC50 = 830.0 nM 6.08
CHEMBL1956519 IC50 = 960.0 nM 6.02
CHEMBL491114 IC50 = 1000.0 nM 6.00
CHEMBL521969 IC50 = 1100.0 nM 5.96
CHEMBL490124 IC50 = 1300.0 nM 5.89
CHEMBL491938 IC50 = 1300.0 nM 5.89
CHEMBL1956508 IC50 = 1300.0 nM 5.89
CHEMBL1956512 IC50 = 1500.0 nM 5.82
CHEMBL491757 IC50 = 1500.0 nM 5.82
CHEMBL490548 IC50 = 1600.0 nM 5.80
CHEMBL489517 IC50 = 2000.0 nM 5.70
CHEMBL490921 IC50 = 2500.0 nM 5.60
CHEMBL1956514 IC50 = 2600.0 nM 5.58
CHEMBL489537 IC50 = 3100.0 nM 5.51
CHEMBL523820 IC50 = 6100.0 nM 5.21
CHEMBL522298 IC50 = 7900.0 nM 5.10