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Evidence Snapshot

Trichophyton rubrum

CHEMBL612649 ORGANISM Trichophyton rubrum
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T23:51:43Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL612649
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Trichophyton rubrum as ChEMBL target CHEMBL612649. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Trichophyton rubrum
ORGANISM · Trichophyton rubrum
As of 2026-09-13
ChEMBL target ID
CHEMBL612649
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Trichophyton rubrum matters

As of 2026-09-13

Trichophyton rubrum is reviewed as Trichophyton rubrum; the current evidence base includes 9 approved drugs, 2830 compounds, and 324 assays, with lead potency reaching pChEMBL 8.0.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 9 approved drugs, 2830 compounds, and 324 assays for this target. The dominant activity type is IC50. CHEMBL157101 is the current potency anchor at pChEMBL 8.0.

Use CHEMBL157101 as the tractability anchor when discussing potency (pChEMBL 8.0).

Activity source · ChEMBL 36 via Core Engine
9 approved pChEMBL 8.0
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Trichophyton rubrum matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

2830
Total Compounds
324
Total Assays
9
Approved Drugs
IC50: 69.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL157101
 8.0 IC50 Approved
No preferred name
CHEMBL822
 7.5 IC50 Approved
No preferred name
CHEMBL1630575
 7.2 IC50 Approved
No preferred name
CHEMBL91
 6.8 IC50 Approved
No preferred name
CHEMBL175633
 6.7 IC50 Clinical

Approved Drugs

Structure Compound First Approval
CASPOFUNGIN
CHEMBL1630575
 2001
TERBINAFINE
CHEMBL822
 1992
ITRACONAZOLE
CHEMBL64391
 1992
KETOCONAZOLE
CHEMBL157101
 1981
CLOTRIMAZOLE
CHEMBL104
 1975
MICONAZOLE
CHEMBL91
 1974
AMPHOTERICIN B
CHEMBL267345
 1964
GRISEOFULVIN
CHEMBL562
 1962
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T23:51:43Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL612649