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Assay Detail

CHEMBL1963739

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: AKT2
ChEMBL ↗
774
Total Activities
761
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 774 5.79 8.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1998159 — — 1 8.20
CHEMBL1974870 — — 2 8.00
CHEMBL1980995 — — 1 8.00
CHEMBL1991063 — — 1 7.90
CHEMBL1965836 — — 1 7.80
CHEMBL1998121 — — 1 7.70
CHEMBL1988173 — — 1 7.10
CHEMBL1978448 — — 1 7.10
CHEMBL1987679 — — 1 7.00
CHEMBL1974935 — — 1 6.90
CHEMBL2000685 — — 1 6.70
CHEMBL1966524 — — 1 6.70
CHEMBL1967302 — — 1 6.60
CHEMBL1990254 — — 2 6.60
CHEMBL1976240 — — 1 6.50
CHEMBL539474 — — 1 6.50
CHEMBL1987756 — — 1 6.40
CHEMBL1969502 — — 1 6.40
CHEMBL2002479 — — 1 6.30
CHEMBL2000271 — — 1 6.30
CHEMBL1991180 — — 1 6.30
CHEMBL2002726 — — 1 6.30
CHEMBL220241 GSK-269962A — 1 6.20
CHEMBL1983945 — — 1 6.20
CHEMBL1982122 — — 1 6.20
CHEMBL2006263 — — 1 6.10
CHEMBL1968245 — — 1 6.10
CHEMBL1991728 — — 1 6.10
CHEMBL1971943 BAY-549 — 1 6.00
CHEMBL1996831 — — 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1998159 — Ki = 6.31 nM 8.20
CHEMBL1980995 — Ki = 10.0 nM 8.00
CHEMBL1974870 — Ki = 10.0 nM 8.00
CHEMBL1974870 — Ki = 10.0 nM 8.00
CHEMBL1991063 — Ki = 12.59 nM 7.90
CHEMBL1965836 — Ki = 15.85 nM 7.80
CHEMBL1998121 — Ki = 19.95 nM 7.70
CHEMBL1978448 — Ki = 79.43 nM 7.10
CHEMBL1988173 — Ki = 79.43 nM 7.10
CHEMBL1987679 — Ki = 100.0 nM 7.00
CHEMBL1974935 — Ki = 125.89 nM 6.90
CHEMBL1966524 — Ki = 199.53 nM 6.70
CHEMBL2000685 — Ki = 199.53 nM 6.70
CHEMBL1967302 — Ki = 251.19 nM 6.60
CHEMBL1990254 — Ki = 251.19 nM 6.60
CHEMBL1976240 — Ki = 316.23 nM 6.50
CHEMBL539474 — Ki = 316.23 nM 6.50
CHEMBL1969502 — Ki = 398.11 nM 6.40
CHEMBL1990254 — Ki = 398.11 nM 6.40
CHEMBL1987756 — Ki = 398.11 nM 6.40
CHEMBL2002479 — Ki = 501.19 nM 6.30
CHEMBL2000271 — Ki = 501.19 nM 6.30
CHEMBL2002726 — Ki = 501.19 nM 6.30
CHEMBL1991180 — Ki = 501.19 nM 6.30
CHEMBL220241 GSK-269962A Ki = 630.96 nM 6.20
CHEMBL1983945 — Ki = 630.96 nM 6.20
CHEMBL1982122 — Ki = 630.96 nM 6.20
CHEMBL1991728 — Ki = 794.33 nM 6.10
CHEMBL2006263 — Ki = 794.33 nM 6.10
CHEMBL1968245 — Ki = 794.33 nM 6.10
CHEMBL1975138 — Ki = 1000.0 nM 6.00
CHEMBL373598 — Ki = 1000.0 nM 6.00
CHEMBL1996831 — Ki = 1000.0 nM 6.00
CHEMBL413779 — Ki = 1000.0 nM 6.00
CHEMBL1971943 BAY-549 Ki = 1000.0 nM 6.00
CHEMBL1966722 — Ki = 1258.93 nM 5.90
CHEMBL1970217 — Ki = 1258.93 nM 5.90
CHEMBL1975900 — Ki = 1258.93 nM 5.90
CHEMBL2004934 — Ki = 1258.93 nM 5.90
CHEMBL1987034 — Ki = 1258.93 nM 5.90
CHEMBL1991640 — Ki = 1584.89 nM 5.80
CHEMBL1972840 — Ki = 1584.89 nM 5.80
CHEMBL1972158 — Ki = 1584.89 nM 5.80
CHEMBL2000832 — Ki = 1584.89 nM 5.80
CHEMBL1995813 — Ki = 1584.89 nM 5.80
CHEMBL340384 — Ki = 1995.26 nM 5.70
CHEMBL1988608 — Ki = 1995.26 nM 5.70
CHEMBL592030 — Ki = 1995.26 nM 5.70
CHEMBL1993166 — Ki = 1995.26 nM 5.70
CHEMBL2001520 — Ki = 1995.26 nM 5.70