Assay Detail
ADMET
CHEMBL2013522
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Inhibition of CYP2D6
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.64 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1760324 | — | — | 1 | 7.70 |
| CHEMBL2010824 | — | — | 1 | 7.10 |
| CHEMBL2012838 | — | — | 1 | 6.80 |
| CHEMBL1760322 | — | — | 1 | 6.64 |
| CHEMBL2012836 | — | — | 1 | 6.62 |
| CHEMBL2012837 | — | — | 1 | 6.47 |
| CHEMBL1760318 | — | — | 1 | 5.90 |
| CHEMBL1269994 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1760324 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2010824 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2012838 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1760322 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2012836 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2012837 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1760318 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL1269994 | — | IC50 | = | 1350.0 | nM | 5.87 |