Assay Detail
ADMET
CHEMBL2014022
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Inhibition of recombinant CYP2C9
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of P2X3 selective antagonists for the treatment of chronic pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.26 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2011112 | — | — | 1 | 5.70 |
| CHEMBL2011113 | — | — | 1 | 5.62 |
| CHEMBL2011115 | — | — | 1 | 5.62 |
| CHEMBL2011119 | — | — | 1 | 5.62 |
| CHEMBL2011126 | — | — | 1 | 5.16 |
| CHEMBL2011127 | — | — | 1 | 5.16 |
| CHEMBL2011118 | — | — | 1 | 5.14 |
| CHEMBL2011123 | — | — | 1 | 4.96 |
| CHEMBL2011122 | — | — | 1 | 4.85 |
| CHEMBL2011125 | — | — | 1 | 4.80 |
| CHEMBL2011120 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2011112 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2011113 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2011115 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2011119 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2011126 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2011127 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2011118 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL2011123 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2011122 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL2011125 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL2011120 | — | IC50 | > | 10000.0 | nM | - |