Assay Detail
Binding
CHEMBL2015355
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP11B1 expressed in hamster V79 MZ cells using [3H] 11 deoxycorticosterone as substrate by HPLC radioflow detector
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | V79 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of the First Selective Steroid-11β-hydroxylase (CYP11B1) Inhibitors for the Treatment of Cortisol Dependent Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 6.81 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL681 | ETOMIDATE | 4.0 | 1 | 9.30 |
| CHEMBL934 | METYRAPONE | 4.0 | 1 | 7.82 |
| CHEMBL2011431 | — | — | 1 | 7.80 |
| CHEMBL2011246 | — | — | 1 | 7.77 |
| CHEMBL2011437 | — | — | 1 | 7.54 |
| CHEMBL2011433 | — | — | 1 | 7.40 |
| CHEMBL2011253 | — | — | 1 | 7.38 |
| CHEMBL2011242 | — | — | 1 | 7.21 |
| CHEMBL2011264 | — | — | 1 | 7.21 |
| CHEMBL2011244 | — | — | 1 | 7.14 |
| CHEMBL2011430 | — | — | 1 | 7.14 |
| CHEMBL2011435 | — | — | 1 | 7.12 |
| CHEMBL2011261 | — | — | 1 | 7.12 |
| CHEMBL2011260 | — | — | 1 | 7.02 |
| CHEMBL2011247 | — | — | 1 | 7.00 |
| CHEMBL2011248 | — | — | 1 | 6.97 |
| CHEMBL273205 | — | — | 1 | 6.96 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 6.90 |
| CHEMBL2011262 | — | — | 1 | 6.90 |
| CHEMBL2011257 | — | — | 1 | 6.86 |
| CHEMBL428780 | — | — | 1 | 6.82 |
| CHEMBL402298 | — | — | 1 | 6.78 |
| CHEMBL2011243 | — | — | 1 | 6.78 |
| CHEMBL2011434 | — | — | 1 | 6.78 |
| CHEMBL272749 | — | — | 1 | 6.67 |
| CHEMBL2011252 | — | — | 1 | 6.61 |
| CHEMBL2011254 | — | — | 1 | 6.61 |
| CHEMBL2011432 | — | — | 1 | 6.57 |
| CHEMBL2011245 | — | — | 1 | 6.50 |
| CHEMBL402522 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL681 | ETOMIDATE | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL934 | METYRAPONE | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2011431 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2011246 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2011437 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2011433 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2011253 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL2011242 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL2011264 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL2011244 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL2011430 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL2011261 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL2011435 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL2011260 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL2011247 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL2011248 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL273205 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL2011262 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL2011257 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL428780 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL2011434 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL402298 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL2011243 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL272749 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL2011252 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL2011254 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL2011432 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL2011245 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL402522 | — | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL2011255 | — | IC50 | = | 362.0 | nM | 6.44 |
| CHEMBL2011263 | — | IC50 | = | 362.0 | nM | 6.44 |
| CHEMBL2011250 | — | IC50 | = | 409.0 | nM | 6.39 |
| CHEMBL2011436 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2011241 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2011256 | — | IC50 | = | 502.0 | nM | 6.30 |
| CHEMBL2011249 | — | IC50 | = | 542.0 | nM | 6.27 |
| CHEMBL2010808 | — | IC50 | = | 611.0 | nM | 6.21 |
| CHEMBL1556445 | — | IC50 | = | 663.0 | nM | 6.18 |
| CHEMBL258097 | — | IC50 | = | 782.0 | nM | 6.11 |
| CHEMBL2011251 | — | IC50 | = | 782.0 | nM | 6.11 |
| CHEMBL1440486 | — | IC50 | = | 816.0 | nM | 6.09 |
| CHEMBL2011258 | — | IC50 | = | 971.0 | nM | 6.01 |
| CHEMBL2011240 | — | IC50 | = | 971.0 | nM | 6.01 |
| CHEMBL2011259 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL255759 | — | IC50 | > | 1000.0 | nM | - |