Assay Detail
Binding
CHEMBL2016084
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Binding affinity to human recombinant Tie2 by SPR assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of loperamide as an antagonist of angiopoietin1 and angiopoietin2 by virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 4.46 | 5.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL841 | LOPERAMIDE | 4.0 | 1 | 5.23 |
| CHEMBL174 | AMPICILLIN | 4.0 | 1 | 4.09 |
| CHEMBL1000 | CETIRIZINE | 4.0 | 1 | 4.05 |
| CHEMBL2012790 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL841 | LOPERAMIDE | Kd | = | 5900.0 | nM | 5.23 |
| CHEMBL174 | AMPICILLIN | Kd | = | 82000.0 | nM | 4.09 |
| CHEMBL1000 | CETIRIZINE | Kd | = | 90000.0 | nM | 4.05 |
| CHEMBL2012790 | — | Kd | = | 120000.0 | nM | - |