Assay Detail
Binding
CHEMBL2019411
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Inhibition of ovine COX1 by fluorescence assay
21
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.13 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26915 | SC-560 | — | 1 | 8.07 |
| CHEMBL42485 | DUP-697 | — | 2 | 7.38 |
| CHEMBL2018668 | — | — | 1 | 6.05 |
| CHEMBL2018667 | — | — | 1 | 5.19 |
| CHEMBL2018568 | — | — | 1 | 4.72 |
| CHEMBL2018674 | — | — | 1 | 4.69 |
| CHEMBL2018673 | — | — | 1 | 4.58 |
| CHEMBL2018566 | — | — | 1 | 4.33 |
| CHEMBL2018670 | — | — | 1 | 4.32 |
| CHEMBL2018565 | — | — | 1 | 4.17 |
| CHEMBL2018567 | — | — | 1 | 4.11 |
| CHEMBL2018563 | — | — | 1 | 4.00 |
| CHEMBL2018564 | — | — | 1 | - |
| CHEMBL2016598 | — | — | 1 | - |
| CHEMBL2018675 | — | — | 1 | - |
| CHEMBL2018672 | — | — | 1 | - |
| CHEMBL2018671 | — | — | 1 | - |
| CHEMBL2018669 | — | — | 1 | - |
| CHEMBL2018570 | — | — | 1 | - |
| CHEMBL2018569 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26915 | SC-560 | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL42485 | DUP-697 | IC50 | = | 41.6 | nM | 7.38 |
| CHEMBL2018668 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2018667 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL2018568 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL2018674 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL2018673 | — | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL2018566 | — | IC50 | = | 46700.0 | nM | 4.33 |
| CHEMBL2018670 | — | IC50 | = | 47700.0 | nM | 4.32 |
| CHEMBL2018565 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL2018567 | — | IC50 | = | 77400.0 | nM | 4.11 |
| CHEMBL2018563 | — | IC50 | = | 99100.0 | nM | 4.00 |
| CHEMBL42485 | DUP-697 | IC50 | - | — | - | |
| CHEMBL2018675 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2018672 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2018671 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2018669 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2018570 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2018569 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2016598 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2018564 | — | IC50 | > | 100000.0 | nM | - |