Assay Detail
Functional
CHEMBL2020155
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Antiproliferative activity against human A2780 cells after 3 days by CellTiter-Glo assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.34 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2017967 | — | — | 1 | 7.08 |
| CHEMBL1672323 | — | — | 1 | 6.84 |
| CHEMBL2017968 | — | — | 1 | 6.77 |
| CHEMBL2017966 | — | — | 1 | 6.72 |
| CHEMBL2016592 | — | — | 1 | 6.72 |
| CHEMBL2017965 | — | — | 1 | 6.55 |
| CHEMBL2017977 | — | — | 1 | 6.35 |
| CHEMBL2017973 | — | — | 1 | 6.29 |
| CHEMBL2017974 | BUPARLISIB | 3.0 | 1 | 6.28 |
| CHEMBL1672316 | — | — | 1 | 6.27 |
| CHEMBL2017970 | — | — | 1 | 6.24 |
| CHEMBL2017976 | — | — | 1 | 6.17 |
| CHEMBL2017971 | — | — | 1 | 6.03 |
| CHEMBL2017975 | — | — | 1 | 5.84 |
| CHEMBL2017972 | — | — | 1 | 5.75 |
| CHEMBL2017969 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2017967 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL1672323 | — | EC50 | = | 146.0 | nM | 6.84 |
| CHEMBL2017968 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2017966 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2016592 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2017965 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL2017977 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL2017973 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL2017974 | BUPARLISIB | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL1672316 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL2017970 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL2017976 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL2017971 | — | EC50 | = | 930.0 | nM | 6.03 |
| CHEMBL2017975 | — | EC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL2017972 | — | EC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL2017969 | — | EC50 | = | 3200.0 | nM | 5.50 |