Assay Detail
Binding
CHEMBL2020733
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Inhibition of human serum BChE by Ellman's method
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 8.83 | 10.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2019034 | — | — | 1 | 10.42 |
| CHEMBL2019032 | — | — | 1 | 10.10 |
| CHEMBL2019035 | — | — | 1 | 10.00 |
| CHEMBL2019037 | — | — | 1 | 10.00 |
| CHEMBL2019038 | — | — | 1 | 10.00 |
| CHEMBL2019030 | — | — | 1 | 9.82 |
| CHEMBL2019047 | — | — | 1 | 9.10 |
| CHEMBL2019046 | — | — | 1 | 9.00 |
| CHEMBL2019043 | — | — | 1 | 8.82 |
| CHEMBL2019044 | — | — | 1 | 8.82 |
| CHEMBL2019049 | — | — | 1 | 8.60 |
| CHEMBL2019048 | — | — | 1 | 8.30 |
| CHEMBL2019040 | — | — | 1 | 7.82 |
| CHEMBL2019052 | — | — | 1 | 7.52 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.40 |
| CHEMBL2019041 | — | — | 1 | 7.30 |
| CHEMBL2019053 | — | — | 1 | 7.02 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | - |
| CHEMBL28 | APIGENIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2019034 | — | IC50 | = | 0.038 | nM | 10.42 |
| CHEMBL2019032 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL2019035 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL2019037 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL2019038 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL2019030 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL2019047 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL2019046 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2019043 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL2019044 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL2019049 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL2019048 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2019040 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2019052 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL95 | TACRINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2019041 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2019053 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL45 | MELATONIN | IC50 | - | — | - | |
| CHEMBL28 | APIGENIN | IC50 | - | — | - |