Assay Detail
ADMET
CHEMBL2020948
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Inhibition of CYP3A4
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
From ApoA1 upregulation to BET family bromodomain inhibition: discovery of I-BET151.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.48 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2017279 | — | — | 1 | 5.82 |
| CHEMBL2017288 | — | — | 1 | 5.82 |
| CHEMBL2017283 | — | — | 1 | 5.77 |
| CHEMBL2017280 | — | — | 1 | 5.75 |
| CHEMBL2017274 | — | — | 1 | 5.72 |
| CHEMBL2017275 | — | — | 1 | 5.72 |
| CHEMBL2017268 | — | — | 1 | 5.70 |
| CHEMBL2017284 | — | — | 1 | 5.70 |
| CHEMBL2017287 | — | — | 1 | 5.70 |
| CHEMBL2017290 | — | — | 1 | 5.62 |
| CHEMBL2017276 | — | — | 1 | 5.51 |
| CHEMBL2017285 | — | — | 1 | 5.43 |
| CHEMBL2017281 | — | — | 1 | 5.41 |
| CHEMBL2017273 | — | — | 1 | 5.33 |
| CHEMBL2017291 | — | — | 1 | 5.01 |
| CHEMBL2017286 | — | — | 1 | 4.89 |
| CHEMBL2017269 | — | — | 1 | 4.89 |
| CHEMBL2017089 | — | — | 1 | 4.77 |
| CHEMBL2017091 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2017279 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2017288 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2017283 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2017280 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2017274 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2017275 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2017268 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2017284 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2017287 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2017290 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2017276 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL2017285 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL2017281 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL2017273 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL2017291 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL2017286 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL2017269 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL2017089 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL2017091 | — | IC50 | > | 33000.0 | nM | - |