Assay Detail
Functional
CHEMBL2024927
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Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as reduction in viral DNA replication
59
Total Activities
59
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | HepG2 2.2.15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 59 | 4.65 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 6.05 |
| CHEMBL2022385 | — | — | 1 | 5.27 |
| CHEMBL2022382 | — | — | 1 | 5.24 |
| CHEMBL2022388 | — | — | 1 | 5.05 |
| CHEMBL2022394 | — | — | 1 | 5.04 |
| CHEMBL2024640 | — | — | 1 | 4.88 |
| CHEMBL2024635 | — | — | 1 | 4.85 |
| CHEMBL2022391 | — | — | 1 | 4.82 |
| CHEMBL2023712 | — | — | 1 | 4.74 |
| CHEMBL2022384 | — | — | 1 | 4.74 |
| CHEMBL2022380 | — | — | 1 | 4.71 |
| CHEMBL2022387 | — | — | 1 | 4.67 |
| CHEMBL2022393 | — | — | 1 | 4.62 |
| CHEMBL2024637 | — | — | 1 | 4.54 |
| CHEMBL2024634 | — | — | 1 | 4.54 |
| CHEMBL2024642 | — | — | 1 | 4.51 |
| CHEMBL230006 | ENOXOLONE | 2.0 | 1 | 4.41 |
| CHEMBL450046 | GLYCYRRHETINIC ACID PROPIONATE | — | 1 | 4.35 |
| CHEMBL487933 | — | — | 1 | 4.33 |
| CHEMBL2024643 | — | — | 1 | 4.33 |
| CHEMBL2024639 | — | — | 1 | 4.32 |
| CHEMBL2024623 | — | — | 1 | 4.32 |
| CHEMBL2022398 | — | — | 1 | 4.19 |
| CHEMBL2024628 | — | — | 1 | 4.18 |
| CHEMBL2024631 | — | — | 1 | 4.17 |
| CHEMBL2024632 | — | — | 1 | 4.05 |
| CHEMBL2022402 | — | — | 1 | - |
| CHEMBL2024633 | — | — | 1 | - |
| CHEMBL2022395 | — | — | 1 | - |
| CHEMBL2022396 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483 | TENOFOVIR ANHYDROUS | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL2022385 | — | IC50 | = | 5360.0 | nM | 5.27 |
| CHEMBL2022382 | — | IC50 | = | 5710.0 | nM | 5.24 |
| CHEMBL2022388 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL2022394 | — | IC50 | = | 9080.0 | nM | 5.04 |
| CHEMBL2024640 | — | IC50 | = | 13230.0 | nM | 4.88 |
| CHEMBL2024635 | — | IC50 | = | 14170.0 | nM | 4.85 |
| CHEMBL2022391 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL2023712 | — | IC50 | = | 18370.0 | nM | 4.74 |
| CHEMBL2022384 | — | IC50 | = | 18120.0 | nM | 4.74 |
| CHEMBL2022380 | — | IC50 | = | 19540.0 | nM | 4.71 |
| CHEMBL2022387 | — | IC50 | = | 21240.0 | nM | 4.67 |
| CHEMBL2022393 | — | IC50 | = | 23740.0 | nM | 4.62 |
| CHEMBL2024634 | — | IC50 | = | 28590.0 | nM | 4.54 |
| CHEMBL2024637 | — | IC50 | = | 28760.0 | nM | 4.54 |
| CHEMBL2024642 | — | IC50 | = | 30870.0 | nM | 4.51 |
| CHEMBL230006 | ENOXOLONE | IC50 | = | 39280.0 | nM | 4.41 |
| CHEMBL450046 | GLYCYRRHETINIC ACID PROPIONATE | IC50 | = | 44400.0 | nM | 4.35 |
| CHEMBL487933 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL2024643 | — | IC50 | = | 47160.0 | nM | 4.33 |
| CHEMBL2024639 | — | IC50 | = | 47680.0 | nM | 4.32 |
| CHEMBL2024623 | — | IC50 | = | 48220.0 | nM | 4.32 |
| CHEMBL2022398 | — | IC50 | = | 64910.0 | nM | 4.19 |
| CHEMBL2024628 | — | IC50 | = | 66150.0 | nM | 4.18 |
| CHEMBL2024631 | — | IC50 | = | 67020.0 | nM | 4.17 |
| CHEMBL2024632 | — | IC50 | = | 89530.0 | nM | 4.05 |
| CHEMBL2023708 | — | IC50 | > | 306940.0 | nM | - |
| CHEMBL2024624 | — | IC50 | = | 120100.0 | nM | - |
| CHEMBL2022389 | — | IC50 | = | 159710.0 | nM | - |
| CHEMBL2022390 | — | IC50 | = | 195170.0 | nM | - |
| CHEMBL2024626 | — | IC50 | > | 246580.0 | nM | - |
| CHEMBL2022392 | — | IC50 | = | 171300.0 | nM | - |
| CHEMBL2024629 | — | IC50 | > | 361670.0 | nM | - |
| CHEMBL207413 | ACETOXOLONE | IC50 | = | 121140.0 | nM | - |
| CHEMBL2024627 | — | IC50 | = | 332040.0 | nM | - |
| CHEMBL2023711 | — | IC50 | > | 236040.0 | nM | - |
| CHEMBL2023710 | — | IC50 | > | 120310.0 | nM | - |
| CHEMBL2023709 | — | IC50 | > | 293830.0 | nM | - |
| CHEMBL2022402 | — | IC50 | > | 258630.0 | nM | - |
| CHEMBL2023707 | — | IC50 | > | 270880.0 | nM | - |
| CHEMBL2023706 | — | IC50 | > | 250470.0 | nM | - |
| CHEMBL2024638 | — | IC50 | = | 297860.0 | nM | - |
| CHEMBL2022401 | — | IC50 | > | 292970.0 | nM | - |
| CHEMBL2022400 | — | IC50 | > | 224720.0 | nM | - |
| CHEMBL2022399 | — | IC50 | > | 246710.0 | nM | - |
| CHEMBL2024636 | — | IC50 | = | 198160.0 | nM | - |
| CHEMBL2022397 | — | IC50 | > | 292180.0 | nM | - |
| CHEMBL2022396 | — | IC50 | > | 381600.0 | nM | - |
| CHEMBL2022395 | — | IC50 | > | 374980.0 | nM | - |
| CHEMBL2024633 | — | IC50 | > | 478640.0 | nM | - |