Assay Detail
Functional
CHEMBL2026090
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against VSV OKA expressing thymidine kinase infected in HEL cells assessed as reduction of virus plaque formation after 4 days
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.75 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 7.72 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 6.31 |
| CHEMBL2023442 | — | — | 1 | 5.40 |
| CHEMBL2023606 | — | — | 1 | 5.40 |
| CHEMBL2023610 | — | — | 1 | 5.40 |
| CHEMBL2023605 | — | — | 1 | 5.03 |
| CHEMBL2023604 | — | — | 1 | 5.02 |
| CHEMBL2023441 | — | — | 1 | - |
| CHEMBL2023440 | — | — | 1 | - |
| CHEMBL2023608 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL2023442 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2023606 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2023610 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2023605 | — | EC50 | = | 9260.0 | nM | 5.03 |
| CHEMBL2023604 | — | EC50 | = | 9620.0 | nM | 5.02 |
| CHEMBL2023441 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL2023440 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL2023608 | — | EC50 | > | 20000.0 | nM | - |