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Assay Detail

CHEMBL2026689

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HCV JFH-1 J399EM infected in Human Huh7.5.1 cells assessed as suppression of viral replication after 72 hrs by EGFP assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Cell Type Huh-7
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis C virus (CHEMBL379)
Type ORGANISM
Organism Hepacivirus hominis

Publication

Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy.
Liu MM, Zhou L, He PL, Zhang YN, Zhou JY, Shen Q, Chen XW, Zuo JP, Li W, Ye DY.
Eur J Med Chem (2012) 52 : 33 -43
PubMed 22445328 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 16 4.65 5.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL151 LUTEOLIN 2.0 1 5.33
CHEMBL28 APIGENIN 1 5.10
CHEMBL2024312 1 4.90
CHEMBL44 GENISTEIN 2.0 1 4.84
CHEMBL489142 SYRINGETIN 1 4.81
CHEMBL50 QUERCETIN 3.0 1 4.70
CHEMBL40275 ALOE-EMODIN 1 4.68
CHEMBL222541 1 4.63
CHEMBL247484 TRICETIN 1 4.49
CHEMBL172350 EUPAFOLIN 1 4.48
CHEMBL8260 BAICALEIN 2.0 1 4.47
CHEMBL293776 HISPIDULIN 1 4.44
CHEMBL129795 ISOLIQUIRITIGENIN 1 4.44
CHEMBL398328 1 4.42
CHEMBL164 MYRICETIN 1 4.33
CHEMBL253570 GOSSYPETIN 1 4.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL151 LUTEOLIN EC50 = 4700.0 nM 5.33
CHEMBL28 APIGENIN EC50 = 7900.0 nM 5.10
CHEMBL2024312 EC50 = 12700.0 nM 4.90
CHEMBL44 GENISTEIN EC50 = 14400.0 nM 4.84
CHEMBL489142 SYRINGETIN EC50 = 15500.0 nM 4.81
CHEMBL50 QUERCETIN EC50 = 19800.0 nM 4.70
CHEMBL40275 ALOE-EMODIN EC50 = 20800.0 nM 4.68
CHEMBL222541 EC50 = 23300.0 nM 4.63
CHEMBL247484 TRICETIN EC50 = 32200.0 nM 4.49
CHEMBL172350 EUPAFOLIN EC50 = 33100.0 nM 4.48
CHEMBL8260 BAICALEIN EC50 = 33900.0 nM 4.47
CHEMBL293776 HISPIDULIN EC50 = 36300.0 nM 4.44
CHEMBL129795 ISOLIQUIRITIGENIN EC50 = 36100.0 nM 4.44
CHEMBL398328 EC50 = 38500.0 nM 4.42
CHEMBL164 MYRICETIN EC50 = 46900.0 nM 4.33
CHEMBL253570 GOSSYPETIN EC50 = 47000.0 nM 4.33