Compound Detail
CHEMBL489142
SYRINGETIN Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL489142 |
| Name | SYRINGETIN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UZMAPBJVXOGOFT-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
346.3
MW (Da)
2.30
ALogP
8
HBA
4
HBD
129.6
PSA (Ų)
0.57
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 4.81
IC50 1 meas. best 5.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Monocyte CHEMBL614076 | IC50 | 5.68 | 5.68 | 2100.0 | 1 |
| Hepatitis C virus CHEMBL379 | EC50 | 4.81 | 4.81 | 15500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Monocyte | IC50 | = | 2100.0 | nM | 5.68 | Inhibition of procoagulant activity in monocyte from human blood assessed as cou... | 8882428 |
| Hepatitis C virus | EC50 | = | 15500.0 | nM | 4.81 | Antiviral activity against HCV JFH-1 J399EM infected in Human Huh7.5.1 cells ass... | 22445328 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19807106 | 10.1021/jm900964r | Peroxisome proliferator-activated receptor gamma | 2 |
| 1800636 | 10.1021/np50077a018 | Unchecked | 1 |
| 1479375 | 10.1021/np50089a001 | Tyrosine-protein kinase Lck | 1 |
| 8882428 | 10.1021/np960057s | Monocyte | 1 |
| 22445328 | 10.1016/j.ejmech.2012.03.002 | Hepatitis C virus | 1 |
| 22445328 | 10.1016/j.ejmech.2012.03.002 | ADMET | 1 |
| 28049590 | 10.1016/j.bmcl.2016.12.051 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial | 1 |
Data from ChEMBL 36 via Core Engine