Assay Detail
Binding
CHEMBL2032485
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant c-met-mediated gastrin phosphorylation by HTRF assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-based design of novel class II c-Met inhibitors: 1. Identification of pyrazolone-based derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.89 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2031893 | — | — | 1 | 9.00 |
| CHEMBL573761 | — | — | 1 | 8.77 |
| CHEMBL404881 | — | — | 1 | 8.40 |
| CHEMBL2032039 | — | — | 1 | 8.32 |
| CHEMBL2032033 | — | — | 1 | 7.86 |
| CHEMBL518208 | — | — | 1 | 7.85 |
| CHEMBL2032037 | — | — | 1 | 7.42 |
| CHEMBL2032034 | — | — | 1 | 7.25 |
| CHEMBL2032036 | — | — | 1 | 7.22 |
| CHEMBL2032035 | — | — | 1 | 6.85 |
| CHEMBL2032038 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2031893 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL573761 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL404881 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL2032039 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL2032033 | — | Ki | = | 13.7 | nM | 7.86 |
| CHEMBL518208 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL2032037 | — | Ki | = | 37.8 | nM | 7.42 |
| CHEMBL2032034 | — | Ki | = | 56.7 | nM | 7.25 |
| CHEMBL2032036 | — | Ki | = | 60.2 | nM | 7.22 |
| CHEMBL2032035 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL2032038 | — | Ki | > | 20000.0 | nM | - |