Compound Detail
CHEMBL2032033
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Basic Information
| ChEMBL ID | CHEMBL2032033 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GFMJATLKGABDIJ-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
501.5
MW (Da)
5.18
ALogP
6
HBA
1
HBD
90.0
PSA (Ų)
0.35
QED
2
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.91
Ki 1 meas. best 7.86
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | Ki | 7.86 | 7.86 | 13.7 | 1 |
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 6.91 | 6.91 | 123.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | Ki | = | 13.7 | nM | 7.86 | Inhibition of recombinant c-met-mediated gastrin phosphorylation by HTRF assay | 22320343 |
| Hepatocyte growth factor receptor | IC50 | = | 123.0 | nM | 6.91 | Inhibition of HGF-mediated c-met autophosphorylation in serum-starved human PC3 ... | 22320343 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22320343 | 10.1021/jm201330u | Hepatocyte growth factor receptor | 2 |
Data from ChEMBL 36 via Core Engine