Assay Detail
Binding
CHEMBL2033354
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](+)-pentazocine from sigma1 receptor in rat brain homogenate
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL3602) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.00 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2030626 | — | — | 1 | 8.15 |
| CHEMBL2030625 | — | — | 1 | 7.66 |
| CHEMBL2030634 | — | — | 1 | 7.29 |
| CHEMBL2030628 | — | — | 1 | 6.99 |
| CHEMBL2030630 | — | — | 1 | 6.92 |
| CHEMBL2030627 | — | — | 1 | 6.56 |
| CHEMBL2030629 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2030626 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL2030625 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL2030634 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL2030628 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL2030630 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL2030627 | — | Ki | = | 276.0 | nM | 6.56 |
| CHEMBL2030629 | — | Ki | = | 3826.0 | nM | 5.42 |