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Assay Detail

CHEMBL2033508

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Functional
Antiviral activity against HCV genotype 1b infected in human HuH7 cells assessed as cytoprotection after 24 hrs
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Cell Type Huh-7
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis C virus (CHEMBL379)
Type ORGANISM
Organism Hepacivirus hominis

Publication

Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors.
Cho A, Zhang L, Xu J, Babusis D, Butler T, Lee R, Saunders OL, Wang T, Parrish J, Perry J, Feng JY, Ray AS, Kim CU.
Bioorg Med Chem Lett (2012) 22 : 4127 -4132
PubMed 22578461 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 12 5.91 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2031683 1 7.30
CHEMBL236207 BETA-2'-C-METHYL-7-DEAZA-ADENOSINE 1 7.10
CHEMBL73809 1 6.46
CHEMBL2031677 1 5.89
CHEMBL2031678 1 5.70
CHEMBL418899 2'-B-METHYL-GUANOSINE 1 5.49
CHEMBL438605 1 5.39
CHEMBL2031684 1 5.02
CHEMBL2031681 1 4.82
CHEMBL2031679 1 -
CHEMBL2031680 1 -
CHEMBL2031682 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2031683 EC50 = 50.0 nM 7.30
CHEMBL236207 BETA-2'-C-METHYL-7-DEAZA-ADENOSINE EC50 = 80.0 nM 7.10
CHEMBL73809 EC50 = 350.0 nM 6.46
CHEMBL2031677 EC50 = 1280.0 nM 5.89
CHEMBL2031678 EC50 = 1980.0 nM 5.70
CHEMBL418899 2'-B-METHYL-GUANOSINE EC50 = 3250.0 nM 5.49
CHEMBL438605 EC50 = 4070.0 nM 5.39
CHEMBL2031684 EC50 = 9540.0 nM 5.02
CHEMBL2031681 EC50 = 15200.0 nM 4.82
CHEMBL2031679 EC50 > 89000.0 nM -
CHEMBL2031680 EC50 > 89000.0 nM -
CHEMBL2031682 EC50 > 89000.0 nM -