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Assay Detail

CHEMBL2033753

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of M5 muscarinic receptor
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Muscarinic acetylcholine receptor M5 (CHEMBL2035)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
Banister SD, Rendina LM, Kassiou M.
Bioorg Med Chem Lett (2012) 22 : 4059 -4063
PubMed 22607684 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 19 5.75 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2030626 1 6.10
CHEMBL2030625 1 5.57
CHEMBL2030634 1 5.57
CHEMBL2030623 1 -
CHEMBL2030624 1 -
CHEMBL104700 1 -
CHEMBL2030627 1 -
CHEMBL2030628 1 -
CHEMBL2030629 1 -
CHEMBL2030622 1 -
CHEMBL2030631 1 -
CHEMBL2030632 1 -
CHEMBL2030633 1 -
CHEMBL148489 N-(3-PYRIDYLMETHYL)PYRROLIDINE 1 -
CHEMBL2030635 1 -
CHEMBL2030636 1 -
CHEMBL270595 1 -
CHEMBL2030637 1 -
CHEMBL2030630 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2030626 Ki = 802.0 nM 6.10
CHEMBL2030625 Ki = 2665.0 nM 5.57
CHEMBL2030634 Ki = 2691.0 nM 5.57
CHEMBL2030623 Ki - -
CHEMBL2030624 Ki - -
CHEMBL104700 Ki - -
CHEMBL2030627 Ki - -
CHEMBL2030628 Ki - -
CHEMBL2030629 Ki - -
CHEMBL2030622 Ki - -
CHEMBL2030631 Ki - -
CHEMBL2030632 Ki - -
CHEMBL2030633 Ki - -
CHEMBL148489 N-(3-PYRIDYLMETHYL)PYRROLIDINE Ki - -
CHEMBL2030635 Ki - -
CHEMBL2030636 Ki - -
CHEMBL270595 Ki - -
CHEMBL2030637 Ki - -
CHEMBL2030630 Ki - -