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Assay Detail

CHEMBL2039583

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Binding
Inhibition of TrxR1 in rat liver homogenate preincubated for 5 mins measured by DNTB assay
ChEMBL ↗
70
Total Activities
35
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Tissue Liver
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Thioredoxin reductase 1, cytoplasmic (CHEMBL6035) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Inhibition of thioredoxin reductase by a novel series of bis-1,2-benzisoselenazol-3(2H)-ones: Organoselenium compounds for cancer therapy.
He J, Li D, Xiong K, Ge Y, Jin H, Zhang G, Hong M, Tian Y, Yin J, Zeng H.
Bioorg Med Chem (2012) 20 : 3816 -3827
PubMed 22579620 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Inhibition 35 - -
IC50 35 5.63 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2035489 — — 2 6.89
CHEMBL2034987 — — 2 6.55
CHEMBL2035491 — — 2 6.50
CHEMBL2035460 ETHASELEN 1.0 2 6.46
CHEMBL2035484 — — 2 6.24
CHEMBL2035461 — — 2 6.11
CHEMBL2035485 — — 2 6.09
CHEMBL2035476 — — 2 6.07
CHEMBL2035462 — — 2 5.99
CHEMBL2035471 — — 2 5.94
CHEMBL2035470 — — 2 5.90
CHEMBL2035480 — — 2 5.88
CHEMBL2035483 — — 2 5.80
CHEMBL2035482 — — 2 5.80
CHEMBL2035477 — — 2 5.79
CHEMBL2035464 — — 2 5.78
CHEMBL2035481 — — 2 5.75
CHEMBL2035463 — — 2 5.71
CHEMBL2035472 — — 2 5.62
CHEMBL2035487 — — 2 5.54
CHEMBL2035486 — — 2 5.54
CHEMBL2035473 — — 2 5.50
CHEMBL2035478 — — 2 5.41
CHEMBL2035466 — — 2 5.35
CHEMBL2035488 — — 2 5.34
CHEMBL2035474 — — 2 5.31
CHEMBL2035465 — — 2 5.23
CHEMBL2035479 — — 2 4.98
CHEMBL2035467 — — 2 4.89
CHEMBL2035490 — — 2 4.65

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2035489 — IC50 = 130.0 nM 6.89
CHEMBL2034987 — IC50 = 280.0 nM 6.55
CHEMBL2035491 — IC50 = 320.0 nM 6.50
CHEMBL2035460 ETHASELEN IC50 = 350.0 nM 6.46
CHEMBL2035484 — IC50 = 570.0 nM 6.24
CHEMBL2035461 — IC50 = 780.0 nM 6.11
CHEMBL2035485 — IC50 = 820.0 nM 6.09
CHEMBL2035476 — IC50 = 860.0 nM 6.07
CHEMBL2035462 — IC50 = 1030.0 nM 5.99
CHEMBL2035471 — IC50 = 1160.0 nM 5.94
CHEMBL2035470 — IC50 = 1260.0 nM 5.90
CHEMBL2035480 — IC50 = 1310.0 nM 5.88
CHEMBL2035483 — IC50 = 1590.0 nM 5.80
CHEMBL2035482 — IC50 = 1580.0 nM 5.80
CHEMBL2035477 — IC50 = 1640.0 nM 5.79
CHEMBL2035464 — IC50 = 1660.0 nM 5.78
CHEMBL2035481 — IC50 = 1800.0 nM 5.75
CHEMBL2035463 — IC50 = 1950.0 nM 5.71
CHEMBL2035472 — IC50 = 2380.0 nM 5.62
CHEMBL2035486 — IC50 = 2910.0 nM 5.54
CHEMBL2035487 — IC50 = 2870.0 nM 5.54
CHEMBL2035473 — IC50 = 3160.0 nM 5.50
CHEMBL2035478 — IC50 = 3870.0 nM 5.41
CHEMBL2035466 — IC50 = 4490.0 nM 5.35
CHEMBL2035488 — IC50 = 4540.0 nM 5.34
CHEMBL2035474 — IC50 = 4910.0 nM 5.31
CHEMBL2035465 — IC50 = 5850.0 nM 5.23
CHEMBL2035479 — IC50 = 10490.0 nM 4.98
CHEMBL2035467 — IC50 = 12790.0 nM 4.89
CHEMBL2035490 — IC50 = 22600.0 nM 4.65
CHEMBL2035469 — IC50 = 34300.0 nM 4.46
CHEMBL2035468 — IC50 = 47680.0 nM 4.32
CHEMBL2035493 — IC50 = 48090.0 nM 4.32
CHEMBL2035490 — Inhibition - % -
CHEMBL2035489 — Inhibition - % -
CHEMBL2035488 — Inhibition - % -
CHEMBL2035487 — Inhibition - % -
CHEMBL2035486 — Inhibition - % -
CHEMBL2035485 — Inhibition - % -
CHEMBL2034987 — Inhibition - % -
CHEMBL2035483 — Inhibition - % -
CHEMBL2035482 — Inhibition - % -
CHEMBL2035481 — Inhibition - % -
CHEMBL2035480 — Inhibition - % -
CHEMBL2035479 — Inhibition - % -
CHEMBL2035478 — Inhibition - % -
CHEMBL2035475 — IC50 > 50000.0 nM -
CHEMBL2035477 — Inhibition - % -
CHEMBL2035476 — Inhibition - % -
CHEMBL2035484 — Inhibition - % -