Compound Detail
CHEMBL2035468
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Basic Information
| ChEMBL ID | CHEMBL2035468 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FQIHVYNLFCXJHM-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
484.3
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.32
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Thioredoxin reductase 1, cytoplasmic CHEMBL6035 | IC50 | 4.32 | 4.32 | 47680.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Thioredoxin reductase 1, cytoplasmic | IC50 | = | 47680.0 | nM | 4.32 | Inhibition of TrxR1 in rat liver homogenate preincubated for 5 mins measured by ... | 22579620 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22579620 | 10.1016/j.bmc.2012.04.033 | Thioredoxin reductase 1, cytoplasmic | 2 |
| 22579620 | 10.1016/j.bmc.2012.04.033 | LoVo | 1 |
| 22579620 | 10.1016/j.bmc.2012.04.033 | NON-PROTEIN TARGET | 1 |
| 22579620 | 10.1016/j.bmc.2012.04.033 | MIA PaCa-2 | 1 |
Data from ChEMBL 36 via Core Engine