Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2040486

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against VZV infected in human HFF cells assessed as reduction in cytopathic effect after 7 days by crystal violet staining
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human alphaherpesvirus 3
Cell Type HFF
Confidence 1 — Organism
Curated By Autocuration

Target

Human alphaherpesvirus 3 (CHEMBL613132)
Type ORGANISM
Organism Human alphaherpesvirus 3

Publication

Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.
Williams JD, Khan AR, Harden EA, Hartline CB, Jefferson GM, Keith KA, Prichard MN, Zemlicka J, Peet NP, Bowlin TL.
Bioorg Med Chem (2012) 20 : 3710 -3718
PubMed 22607883 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 35 5.11 5.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL184 ACYCLOVIR 4.0 1 5.72
CHEMBL2036396 1 5.54
CHEMBL226395 METHYLGUANINE 1 5.13
CHEMBL2036403 1 4.86
CHEMBL2036404 1 4.28
CHEMBL2036413 1 -
CHEMBL2036387 1 -
CHEMBL2036398 1 -
CHEMBL265948 FILOCICLOVIR 2.0 1 -
CHEMBL2036395 1 -
CHEMBL2036394 1 -
CHEMBL2036393 1 -
CHEMBL2036392 1 -
CHEMBL2036391 1 -
CHEMBL2036390 1 -
CHEMBL2036389 1 -
CHEMBL2036388 1 -
CHEMBL2036412 1 -
CHEMBL2036411 1 -
CHEMBL2036410 1 -
CHEMBL2036409 1 -
CHEMBL2036408 1 -
CHEMBL2036407 1 -
CHEMBL2036406 1 -
CHEMBL2036405 1 -
CHEMBL2036402 1 -
CHEMBL2036401 1 -
CHEMBL2036400 1 -
CHEMBL2036397 1 -
CHEMBL2036399 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL184 ACYCLOVIR IC50 = 1900.0 nM 5.72
CHEMBL2036396 IC50 = 2900.0 nM 5.54
CHEMBL226395 METHYLGUANINE IC50 = 7400.0 nM 5.13
CHEMBL2036403 IC50 = 13900.0 nM 4.86
CHEMBL2036404 IC50 = 53000.0 nM 4.28
CHEMBL265948 FILOCICLOVIR IC50 > 100000.0 nM -
CHEMBL388596 2,6-DIAMINOPURINE IC50 > 300000.0 nM -
CHEMBL2036395 IC50 > 100000.0 nM -
CHEMBL2036394 IC50 > 300000.0 nM -
CHEMBL2036393 IC50 > 300000.0 nM -
CHEMBL2036392 IC50 = 180000.0 nM -
CHEMBL2036391 IC50 > 60000.0 nM -
CHEMBL2036390 IC50 > 300000.0 nM -
CHEMBL2036389 IC50 > 60000.0 nM -
CHEMBL2036388 IC50 > 300000.0 nM -
CHEMBL2036387 IC50 > 300000.0 nM -
CHEMBL152780 IC50 > 60000.0 nM -
CHEMBL2036386 IC50 > 300000.0 nM -
CHEMBL2036385 IC50 > 300000.0 nM -
CHEMBL2036384 IC50 > 300000.0 nM -
CHEMBL2036398 IC50 > 100000.0 nM -
CHEMBL2036413 IC50 > 60000.0 nM -
CHEMBL2036412 IC50 > 60000.0 nM -
CHEMBL2036411 IC50 > 300000.0 nM -
CHEMBL2036410 IC50 > 300000.0 nM -
CHEMBL2036409 IC50 > 50000.0 nM -
CHEMBL2036408 IC50 > 300000.0 nM -
CHEMBL2036407 IC50 > 60000.0 nM -
CHEMBL2036406 IC50 > 300000.0 nM -
CHEMBL2036405 IC50 > 60000.0 nM -
CHEMBL2036402 IC50 > 300000.0 nM -
CHEMBL2036401 IC50 > 100000.0 nM -
CHEMBL2036400 IC50 - -
CHEMBL2036397 IC50 > 300000.0 nM -
CHEMBL2036399 IC50 > 60000.0 nM -