Assay Detail
Functional
CHEMBL2045463
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Cytotoxicity against p53-mutant human U373 cells after 72 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-373MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of analogs of the marine alkaloids granulatimide and isogranulatimide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.85 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2041914 | — | — | 1 | 6.70 |
| CHEMBL2041923 | — | — | 1 | 5.40 |
| CHEMBL2041924 | — | — | 1 | 5.30 |
| CHEMBL240747 | GRANULATIMIDE | — | 1 | 5.22 |
| CHEMBL2041917 | — | — | 1 | 5.10 |
| CHEMBL2041926 | — | — | 1 | 5.00 |
| CHEMBL2041925 | — | — | 1 | 4.82 |
| CHEMBL2041749 | — | — | 1 | 4.66 |
| CHEMBL2041912 | — | — | 1 | 4.58 |
| CHEMBL2041932 | — | — | 1 | 4.57 |
| CHEMBL2041930 | — | — | 1 | 4.57 |
| CHEMBL2041931 | — | — | 1 | 4.57 |
| CHEMBL2041913 | — | — | 1 | 4.55 |
| CHEMBL393545 | — | — | 1 | 4.48 |
| CHEMBL2041922 | — | — | 1 | 4.37 |
| CHEMBL2041920 | — | — | 1 | 4.29 |
| CHEMBL2041915 | — | — | 1 | 4.24 |
| CHEMBL2041929 | — | — | 1 | - |
| CHEMBL2041919 | — | — | 1 | - |
| CHEMBL2041928 | — | — | 1 | - |
| CHEMBL2041927 | — | — | 1 | - |
| CHEMBL2041918 | — | — | 1 | - |
| CHEMBL2041916 | — | — | 1 | - |
| CHEMBL239698 | — | — | 1 | - |
| CHEMBL413188 | ISOGRANULATIMIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2041914 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2041923 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2041924 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL240747 | GRANULATIMIDE | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL2041917 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2041926 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2041925 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2041749 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL2041912 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL2041932 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL2041930 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL2041931 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL2041913 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL393545 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL2041922 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL2041920 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL2041915 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL2041929 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2041919 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2041928 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2041927 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2041918 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2041916 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL239698 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL413188 | ISOGRANULATIMIDE | IC50 | > | 100000.0 | nM | - |