Assay Detail
Functional
CHEMBL2045537
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 infected in rat L6 cells after 72 hrs by alamar blue assay
85
Total Activities
85
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Synthesis and structure-activity analysis of new phosphonium salts with potent activity against African trypanosomes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 85 | 6.29 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2041843 | — | — | 1 | 8.70 |
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.12 |
| CHEMBL2041616 | — | — | 1 | 7.85 |
| CHEMBL2041820 | — | — | 1 | 7.57 |
| CHEMBL2041823 | — | — | 1 | 7.30 |
| CHEMBL2041825 | — | — | 1 | 7.20 |
| CHEMBL2041821 | — | — | 1 | 7.14 |
| CHEMBL2041842 | — | — | 1 | 7.09 |
| CHEMBL2041824 | — | — | 1 | 7.09 |
| CHEMBL2041822 | — | — | 1 | 7.08 |
| CHEMBL2041973 | — | — | 1 | 7.08 |
| CHEMBL2041617 | — | — | 1 | 7.00 |
| CHEMBL2041818 | — | — | 1 | 6.99 |
| CHEMBL2041805 | — | — | 1 | 6.96 |
| CHEMBL2041807 | — | — | 1 | 6.95 |
| CHEMBL2041624 | — | — | 1 | 6.85 |
| CHEMBL2041845 | — | — | 1 | 6.82 |
| CHEMBL601068 | — | — | 1 | 6.80 |
| CHEMBL2041828 | — | — | 1 | 6.80 |
| CHEMBL2041826 | — | — | 1 | 6.77 |
| CHEMBL2041827 | — | — | 1 | 6.76 |
| CHEMBL2041806 | — | — | 1 | 6.75 |
| CHEMBL601708 | — | — | 1 | 6.71 |
| CHEMBL2041619 | — | — | 1 | 6.70 |
| CHEMBL2041795 | — | — | 1 | 6.70 |
| CHEMBL2041618 | — | — | 1 | 6.68 |
| CHEMBL2041840 | — | — | 1 | 6.67 |
| CHEMBL590266 | — | — | 1 | 6.66 |
| CHEMBL2041972 | — | — | 1 | 6.66 |
| CHEMBL2041829 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2041843 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL166 | MELARSOPROL | EC50 | = | 7.5 | nM | 8.12 |
| CHEMBL2041616 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2041820 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2041823 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2041825 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL2041821 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL2041842 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL2041824 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL2041822 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL2041973 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL2041617 | — | EC50 | = | 99.0 | nM | 7.00 |
| CHEMBL2041818 | — | EC50 | = | 103.0 | nM | 6.99 |
| CHEMBL2041805 | — | EC50 | = | 109.0 | nM | 6.96 |
| CHEMBL2041807 | — | EC50 | = | 112.0 | nM | 6.95 |
| CHEMBL2041624 | — | EC50 | = | 142.0 | nM | 6.85 |
| CHEMBL2041845 | — | EC50 | = | 153.0 | nM | 6.82 |
| CHEMBL601068 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2041828 | — | EC50 | = | 159.0 | nM | 6.80 |
| CHEMBL2041826 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2041827 | — | EC50 | = | 173.0 | nM | 6.76 |
| CHEMBL2041806 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL601708 | — | EC50 | = | 197.0 | nM | 6.71 |
| CHEMBL2041619 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2041795 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2041618 | — | EC50 | = | 209.0 | nM | 6.68 |
| CHEMBL2041840 | — | EC50 | = | 216.0 | nM | 6.67 |
| CHEMBL590266 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2041972 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2041829 | — | EC50 | = | 231.0 | nM | 6.64 |
| CHEMBL2041620 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL601066 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL590505 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2041815 | — | EC50 | = | 267.0 | nM | 6.57 |
| CHEMBL2041844 | — | EC50 | = | 274.0 | nM | 6.56 |
| CHEMBL2041831 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL539632 | — | EC50 | = | 289.0 | nM | 6.54 |
| CHEMBL2041621 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL2041838 | — | EC50 | = | 299.0 | nM | 6.52 |
| CHEMBL590385 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL2041811 | — | EC50 | = | 326.0 | nM | 6.49 |
| CHEMBL601706 | — | EC50 | = | 355.0 | nM | 6.45 |
| CHEMBL2041841 | — | EC50 | = | 364.0 | nM | 6.44 |
| CHEMBL2041839 | — | EC50 | = | 384.0 | nM | 6.42 |
| CHEMBL2041817 | — | EC50 | = | 376.0 | nM | 6.42 |
| CHEMBL2041837 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2041623 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL2041796 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL2041622 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL2041832 | — | EC50 | = | 480.0 | nM | 6.32 |