Compound Detail
CHEMBL2041841
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Basic Information
| ChEMBL ID | CHEMBL2041841 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CEEKCHGNKYVTTM-UHFFFAOYSA-M |
| Parent Compound | CHEMBL2078964 |
| Active Moiety | CHEMBL2078964 |
4
Targets
6
Activities
2
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
367.4
MW (Da)
5.49
ALogP
0
HBA
0
HBD
0.0
PSA (Ų)
0.41
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 5 meas. best 7.66
Ki 1 meas. best 4.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma brucei brucei CHEMBL612851 | EC50 | 7.66 | 7.5033 | 22.0 | 3 |
| Trypanosoma brucei rhodesiense CHEMBL612348 | EC50 | 6.44 | 6.44 | 364.0 | 1 |
| L6 CHEMBL614793 | EC50 | 4.89 | 4.89 | 12900.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 4.6 | 4.6 | 25000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Trypanosoma brucei brucei | EC50 | = | 22.0 | nM | 7.66 | Antitrypanosomal activity against diminazene-, pentamidine-, and melaminophenyl ... | 22390399 |
| Trypanosoma brucei brucei | EC50 | = | 33.0 | nM | 7.48 | Antitrypanosomal activity against diminazene aceturate-resistant TbAT1 gene-defi... | 22390399 |
| Trypanosoma brucei brucei | EC50 | = | 43.0 | nM | 7.37 | Antitrypanosomal activity against wild type Trypanosoma brucei brucei Lister 427... | 22390399 |
| Trypanosoma brucei rhodesiense | EC50 | = | 364.0 | nM | 6.44 | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 infecte... | 22390399 |
| L6 | EC50 | = | 12900.0 | nM | 4.89 | Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay | 22390399 |
| Unchecked | Ki | = | 25000.0 | nM | 4.6 | Inhibition of Trypanosoma brucei brucei LAPT1 assessed as [3H]-pentamidine uptak... | 22390399 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 430483 | 10.1021/jm00190a019 | Trypanosoma brucei rhodesiense | 13 |
| 22390399 | 10.1021/jm2014259 | Trypanosoma brucei brucei | 6 |
| 22390399 | 10.1021/jm2014259 | Unchecked | 4 |
| 430483 | 10.1021/jm00190a019 | Mus musculus | 4 |
| 22390399 | 10.1021/jm2014259 | Trypanosoma brucei rhodesiense | 1 |
| 22390399 | 10.1021/jm2014259 | L6 | 1 |
| 22390399 | 10.1021/jm2014259 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine