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Assay Detail

CHEMBL2045540

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Functional
Antitrypanosomal activity against wild type Trypanosoma brucei brucei Lister 427 after 3 days by alamar blue assay
ChEMBL ↗
86
Total Activities
86
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei brucei
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei brucei (CHEMBL612851) ↗
Type ORGANISM
Organism Trypanosoma brucei brucei

Publication

Synthesis and structure-activity analysis of new phosphonium salts with potent activity against African trypanosomes.
Taladriz A, Healy A, Flores Pérez EJ, Herrero García V, Ríos Martínez C, Alkhaldi AA, Eze AA, Kaiser M, de Koning HP, Chana A, Dardonville C.
J Med Chem (2012) 55 : 2606 -2622
PubMed 22390399 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 86 6.43 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL55 PENTAMIDINE 4.0 1 8.10
CHEMBL2041818 — — 1 7.96
CHEMBL2041843 — — 1 7.82
CHEMBL2041840 — — 1 7.64
CHEMBL2041826 — — 1 7.62
CHEMBL2041616 — — 1 7.55
CHEMBL2041824 — — 1 7.54
CHEMBL2041806 — — 1 7.48
CHEMBL2041805 — — 1 7.43
CHEMBL2041807 — — 1 7.42
CHEMBL590266 — — 1 7.38
CHEMBL2041841 — — 1 7.37
CHEMBL2041845 — — 1 7.25
CHEMBL2041830 — — 1 7.24
CHEMBL2041823 — — 1 7.24
CHEMBL2041842 — — 1 7.19
CHEMBL2041821 — — 1 7.11
CHEMBL2041617 — — 1 7.10
CHEMBL2041618 — — 1 7.10
CHEMBL2041624 — — 1 7.09
CHEMBL2041973 — — 1 7.03
CHEMBL2041825 — — 1 7.00
CHEMBL2041972 — — 1 6.96
CHEMBL2041619 — — 1 6.96
CHEMBL2041820 — — 1 6.90
CHEMBL2041829 — — 1 6.85
CHEMBL601708 — — 1 6.85
CHEMBL2041838 — — 1 6.85
CHEMBL2041822 — — 1 6.82
CHEMBL2041815 — — 1 6.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL55 PENTAMIDINE EC50 = 8.0 nM 8.10
CHEMBL2041818 — EC50 = 11.0 nM 7.96
CHEMBL2041843 — EC50 = 15.0 nM 7.82
CHEMBL2041840 — EC50 = 23.0 nM 7.64
CHEMBL2041826 — EC50 = 24.0 nM 7.62
CHEMBL2041616 — EC50 = 28.0 nM 7.55
CHEMBL2041824 — EC50 = 29.0 nM 7.54
CHEMBL2041806 — EC50 = 33.0 nM 7.48
CHEMBL2041805 — EC50 = 37.0 nM 7.43
CHEMBL2041807 — EC50 = 38.0 nM 7.42
CHEMBL590266 — EC50 = 42.0 nM 7.38
CHEMBL2041841 — EC50 = 43.0 nM 7.37
CHEMBL2041845 — EC50 = 56.0 nM 7.25
CHEMBL2041830 — EC50 = 57.0 nM 7.24
CHEMBL2041823 — EC50 = 58.0 nM 7.24
CHEMBL2041842 — EC50 = 64.0 nM 7.19
CHEMBL2041821 — EC50 = 77.0 nM 7.11
CHEMBL2041617 — EC50 = 80.0 nM 7.10
CHEMBL2041618 — EC50 = 80.0 nM 7.10
CHEMBL2041624 — EC50 = 82.0 nM 7.09
CHEMBL2041973 — EC50 = 94.0 nM 7.03
CHEMBL2041825 — EC50 = 100.0 nM 7.00
CHEMBL2041972 — EC50 = 110.0 nM 6.96
CHEMBL2041619 — EC50 = 110.0 nM 6.96
CHEMBL2041820 — EC50 = 125.0 nM 6.90
CHEMBL2041829 — EC50 = 140.0 nM 6.85
CHEMBL2041838 — EC50 = 140.0 nM 6.85
CHEMBL601708 — EC50 = 140.0 nM 6.85
CHEMBL2041822 — EC50 = 150.0 nM 6.82
CHEMBL2041815 — EC50 = 150.0 nM 6.82
CHEMBL2041839 — EC50 = 160.0 nM 6.80
CHEMBL2041844 — EC50 = 170.0 nM 6.77
CHEMBL2041837 — EC50 = 180.0 nM 6.75
CHEMBL590505 — EC50 = 180.0 nM 6.75
CHEMBL539632 — EC50 = 200.0 nM 6.70
CHEMBL601068 — EC50 = 200.0 nM 6.70
CHEMBL2041817 — EC50 = 210.0 nM 6.68
CHEMBL2041970 — EC50 = 230.0 nM 6.64
CHEMBL2041827 — EC50 = 230.0 nM 6.64
CHEMBL601066 — EC50 = 240.0 nM 6.62
CHEMBL590385 — EC50 = 240.0 nM 6.62
CHEMBL2041971 — EC50 = 240.0 nM 6.62
CHEMBL2041620 — EC50 = 240.0 nM 6.62
CHEMBL2041795 — EC50 = 240.0 nM 6.62
CHEMBL2041799 — EC50 = 250.0 nM 6.60
CHEMBL2041796 — EC50 = 300.0 nM 6.52
CHEMBL2041621 — EC50 = 320.0 nM 6.50
CHEMBL2041828 — EC50 = 320.0 nM 6.50
CHEMBL2041797 — EC50 = 330.0 nM 6.48
CHEMBL2041831 — EC50 = 330.0 nM 6.48