Assay Detail
Binding
CHEMBL2045988
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Inhibition of PHD3
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 56 | 7.85 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2041190 | — | — | 1 | 9.10 |
| CHEMBL2041175 | — | — | 1 | 8.80 |
| CHEMBL2041193 | — | — | 1 | 8.80 |
| CHEMBL2043169 | — | — | 1 | 8.77 |
| CHEMBL2043325 | — | — | 1 | 8.72 |
| CHEMBL2041010 | — | — | 1 | 8.70 |
| CHEMBL2041185 | — | — | 1 | 8.70 |
| CHEMBL2041192 | — | — | 1 | 8.68 |
| CHEMBL2043168 | — | — | 1 | 8.68 |
| CHEMBL2041188 | — | — | 1 | 8.54 |
| CHEMBL2041182 | — | — | 1 | 8.49 |
| CHEMBL2041169 | — | — | 1 | 8.46 |
| CHEMBL2043010 | — | — | 1 | 8.46 |
| CHEMBL2043324 | — | — | 1 | 8.44 |
| CHEMBL2041183 | — | — | 1 | 8.39 |
| CHEMBL2041189 | — | — | 1 | 8.32 |
| CHEMBL2041186 | — | — | 1 | 8.31 |
| CHEMBL2043326 | — | — | 1 | 8.24 |
| CHEMBL2040897 | — | — | 1 | 8.23 |
| CHEMBL2041164 | — | — | 1 | 8.19 |
| CHEMBL2043011 | — | — | 1 | 8.14 |
| CHEMBL2041184 | — | — | 1 | 8.11 |
| CHEMBL2043172 | — | — | 1 | 8.08 |
| CHEMBL2041170 | — | — | 1 | 8.01 |
| CHEMBL2041187 | — | — | 1 | 8.00 |
| CHEMBL2043005 | — | — | 1 | 7.96 |
| CHEMBL2043004 | — | — | 1 | 7.96 |
| CHEMBL2041178 | — | — | 1 | 7.85 |
| CHEMBL2041177 | — | — | 1 | 7.82 |
| CHEMBL2041176 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2041190 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL2041175 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL2041193 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL2043169 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL2043325 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL2041010 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2041185 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2041192 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL2043168 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL2041188 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL2041182 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL2041169 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL2043010 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL2043324 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL2041183 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL2041189 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL2041186 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL2043326 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL2040897 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL2041164 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL2043011 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL2041184 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL2043172 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL2041170 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL2041187 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2043005 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2043004 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2041178 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2041177 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2041176 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2041180 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2043002 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2041167 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2041194 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2041174 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2040854 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2043171 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2041181 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL2041171 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL2041165 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL2041191 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2043007 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL2041173 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL2041172 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL2041179 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL2043008 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL2043328 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL2041166 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL2040896 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL2043170 | — | IC50 | = | 95.0 | nM | 7.02 |