Compound Detail
CHEMBL2041185
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COc1nccnc1N1C(=O)N(c2ccc(-c3ccc(C(=O)O)cc3C)cc2)C(=O)C12CCN(Cc1ncccc1C)CC2
Basic Information
| ChEMBL ID | CHEMBL2041185 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KXZUNTUEDNVFLH-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
592.7
MW (Da)
4.87
ALogP
8
HBA
1
HBD
129.1
PSA (Ų)
0.30
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 9.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prolyl hydroxylase EGLN2 CHEMBL3028 | IC50 | 9.7 | 9.7 | 0.2 | 1 |
| Egl nine homolog 1 CHEMBL5697 | IC50 | 9.7 | 9.7 | 0.2 | 1 |
| Prolyl hydroxylase EGLN3 CHEMBL5705 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 5.85 | 5.85 | 1400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Egl nine homolog 1 | IC50 | = | 0.2 | nM | 9.7 | Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cell... | 22364528 |
| Prolyl hydroxylase EGLN2 | IC50 | = | 0.2 | nM | 9.7 | Inhibition of PHD1 | 22364528 |
| Prolyl hydroxylase EGLN3 | IC50 | = | 2.0 | nM | 8.7 | Inhibition of PHD3 | 22364528 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 1400.0 | nM | 5.85 | Binding affinity to human Erg | 22364528 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22364528 | 10.1021/jm201542d | Mus musculus | 3 |
| 22364528 | 10.1021/jm201542d | Egl nine homolog 1 | 1 |
| 22364528 | 10.1021/jm201542d | Prolyl hydroxylase EGLN2 | 1 |
| 22364528 | 10.1021/jm201542d | Prolyl hydroxylase EGLN3 | 1 |
| 22364528 | 10.1021/jm201542d | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 22364528 | 10.1021/jm201542d | Cytochrome P450 3A4 | 1 |
| 22364528 | 10.1021/jm201542d | Cytochrome P450 2D6 | 1 |
Data from ChEMBL 36 via Core Engine