Assay Detail
ADMET
CHEMBL2046011
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Inhibition of CYP2C9
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 4.53 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2041176 | — | — | 1 | 5.00 |
| CHEMBL2041173 | — | — | 1 | 4.60 |
| CHEMBL2041174 | — | — | 1 | 4.52 |
| CHEMBL2041178 | — | — | 1 | 4.36 |
| CHEMBL2043004 | — | — | 1 | 4.19 |
| CHEMBL2041175 | — | — | 1 | - |
| CHEMBL2043171 | — | — | 1 | - |
| CHEMBL2041177 | — | — | 1 | - |
| CHEMBL2041179 | — | — | 1 | - |
| CHEMBL2041180 | — | — | 1 | - |
| CHEMBL2041181 | — | — | 1 | - |
| CHEMBL2040854 | — | — | 1 | - |
| CHEMBL2041184 | — | — | 1 | - |
| CHEMBL2043011 | — | — | 1 | - |
| CHEMBL2043168 | — | — | 1 | - |
| CHEMBL2043169 | — | — | 1 | - |
| CHEMBL2043170 | — | — | 1 | - |
| CHEMBL2041172 | — | — | 1 | - |
| CHEMBL2040894 | — | — | 1 | - |
| CHEMBL2041170 | — | — | 1 | - |
| CHEMBL2041169 | — | — | 1 | - |
| CHEMBL2041168 | — | — | 1 | - |
| CHEMBL2041167 | — | — | 1 | - |
| CHEMBL2041166 | — | — | 1 | - |
| CHEMBL2041165 | — | — | 1 | - |
| CHEMBL2041164 | — | — | 1 | - |
| CHEMBL2041010 | — | — | 1 | - |
| CHEMBL2040897 | — | — | 1 | - |
| CHEMBL2040896 | — | — | 1 | - |
| CHEMBL2041171 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2041176 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2041173 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL2041174 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2041178 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL2043004 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL2043168 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2043328 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2043169 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2043170 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2043171 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2043172 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2043324 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2043325 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2043326 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041182 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041183 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2040895 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041186 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041187 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2041188 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041189 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041190 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041191 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041192 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041193 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2043327 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041170 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041171 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2040896 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2040897 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041010 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041164 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041165 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041166 | — | IC50 | - | — | - | |
| CHEMBL2041167 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041168 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041169 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2043011 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2040894 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041172 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041175 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041177 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041179 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041180 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041181 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2040854 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2041184 | — | IC50 | > | 50000.0 | nM | - |