Assay Detail
Functional
CHEMBL2049906
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity against rat S1P1 assessed as accumulation of cAMP by HTRF assay
4
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sphingosine 1-phosphate receptor 1 (CHEMBL1914263) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Fused tricyclic indoles as S1P₁ agonists with robust efficacy in animal models of autoimmune disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 9.02 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2048293 | — | — | 2 | 10.00 |
| CHEMBL2048287 | — | — | 2 | 8.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2048293 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL2048287 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2048287 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL2048293 | — | EC50 | = | 3.4 | nM | 8.47 |