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Assay Detail

CHEMBL2050141

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to sigma1 receptor
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Sigma non-opioid intracellular receptor 1 (CHEMBL287)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and evaluation of in vitro bioactivity for vesicular acetylcholine transporter inhibitors containing two carbonyl groups.
Tu Z, Wang W, Cui J, Zhang X, Lu X, Xu J, Parsons SM.
Bioorg Med Chem (2012) 20 : 4422 -4429
PubMed 22739089 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 7.67 7.67

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL129530 1 7.67
CHEMBL87379 BENZOVESAMICOL 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL129530 Ki = 21.6 nM 7.67
CHEMBL87379 BENZOVESAMICOL Ki - -