Assay Detail
Binding
CHEMBL2050145
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Inhibition of PDGFRbeta in human SF539 cells pretreated for 60 mins measured after 1 hr by ELISA
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SF-539 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor beta (CHEMBL1913) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.92 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2047247 | — | — | 1 | 6.10 |
| CHEMBL2047253 | — | — | 1 | 5.44 |
| CHEMBL328710 | — | — | 1 | 5.43 |
| CHEMBL2047241 | — | — | 1 | 5.23 |
| CHEMBL2047252 | — | — | 1 | 5.19 |
| CHEMBL2047246 | — | — | 1 | 5.15 |
| CHEMBL2047245 | — | — | 1 | 5.11 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 4.91 |
| CHEMBL2047244 | — | — | 1 | 4.66 |
| CHEMBL2047250 | — | — | 1 | 4.64 |
| CHEMBL2047249 | — | — | 1 | 4.41 |
| CHEMBL2047243 | — | — | 1 | 4.37 |
| CHEMBL2047251 | — | — | 1 | 4.12 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 4.08 |
| CHEMBL2047248 | — | — | 1 | - |
| CHEMBL2047242 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2047247 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2047253 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL328710 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL2047241 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL2047252 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL2047246 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL2047245 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL2047244 | — | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL2047250 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL2047249 | — | IC50 | = | 38900.0 | nM | 4.41 |
| CHEMBL2047243 | — | IC50 | = | 43100.0 | nM | 4.37 |
| CHEMBL2047251 | — | IC50 | = | 75500.0 | nM | 4.12 |
| CHEMBL535 | SUNITINIB | IC50 | = | 83100.0 | nM | 4.08 |
| CHEMBL2047248 | — | IC50 | = | 126300.0 | nM | - |
| CHEMBL2047242 | — | IC50 | > | 500000.0 | nM | - |